| Tag |
Content |
| dbPAF ID |
dbPAF-0001905 |
| Uniprot Accession |
O55005; ROBO1_RAT;
|
| Genbank Protein ID |
NP_071524.1;
|
| Genbank Nucleotide ID |
NM_022188.1;
|
| Protein Name |
Roundabout homolog 1 |
| Protein Synonyms/Alias |
|
| Gene Name |
Robo1 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). May be required for lung development (By similarity).Functional Description
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (By similarity). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). May be required for lung development (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 5 |
Sequence
(Fasta) | MKWKHLPLLV MISLLTLSKK HLLLAQLIPD PEDLERGNDN GTPAPTSDND DNSLGYTGSR 60
LRQEDFPPRI VEHPSDLIVS KGEPATLNCK AEGRPTPTIE WYKGGERVET DKDDPRSHRM 120
LLPSGSLFFL RIVHGRKSRP DEGVYICVAR NYLGEAVSHN ASLEVAILRD DFRQNPSDVM 180
VAVGEPAVME CQPPRGHPEP TISWKKDGSP LDDKDERITI RGGKLMITYT RKSDAGKYVC 240
VGTNMVGERE SKVADVTVLE RPSFVKRPSN LAVTVDDSAE FKCEARGDPV PTFGWRKDDG 300
ELPKSRYEIR DDHTLKIRKV TAGDMGSYTC VAENMVGKAE ASATLTVQEP PHFVVKPRDQ 360
VVALGRTVTF QCEATGNPQP AIFWRREGSQ NLLFSYQPPQ SSSRFSVSQT GDLTVTNVQR 420
SDVGYYICQT LNVAGSIITK AYLEVTDVIA DRPPPVIRQG PVNQTVAVDG TLTLSCVATG 480
SPVPTILWRK DGVLVSTQDS RIKQLESGVL QIRYAKLGDT GRYTCTASTP SGEATWSAYI 540
EVQEFGVPVQ PPRPTDPNLI PSAPSKPEVT DVSKNTVTLL WQPNLNSGAT PTSYIIEAFS 600
HASGSSWQTV AENVKTETFA IKGLKPNAIY LFLVRAANAY GISDPSQISD PVKTQDVPPT 660
TQGVDHKQVQ RELGNVVLHL HNPTILSSSS VEVHWTVDQQ SQYIQGYKIL YRPSGASHGE 720
SEWLVFEVRT PTKNSVVIPD LRKGVNYEIK ARPFFNEFQG ADSEIKFAKT LEERPSAPPR 780
SVTVSKNDGN GTAILVTWQP PPEDTQNGMV QEYKVWCLGN ETRYHINKTV DGSTFSVVIP 840
FLVPGIRYSV EVAASTGAGP GVKSEPQFIQ LDSHGNPVSP EDQVSLAQQI SDVVKQPAFI 900
AGIGAACWII LMVFSIWLYR HRKKRNGLSS TYAGIRKVPS FTFTPTVTYQ RGGEAVSSGG 960
RPGLLNISEP ATQPWLADTW PNTGNSHNDC SINCCTASNG NSDSNLTTYS RPADCIANYN 1020
NQLDNKQTNL MLPESTVYGD VDLSNKINEM KTFNSPNLKD GRFVNPSGQP TPYATTQLIQ 1080
ANLINNMNNG GGDSSEKHWK PPGQQKQEVA PIQYNIMEQN KLNKDYRAND TILPTIPYNH 1140
SYDQNTGGSY NSSDRGSSTS GSQGHKKGAR TPKAPKQGGM NWADLLPPPP AHPPPHSNSE 1200
EYSMSVDESY DQEMPCPVPP ARMYLQQDEL EEEEAERGPT PPVRGAASSP AAVSYSHQST 1260
ATLTPSPQEE LQPMLQDCPE DLGHMPHPPD RRRQPVSPPP PPRPISPPHT YGYISGPLVS 1320
DMDTDAPEEE EDEADMEVAK MQTRRLLLRG LEQTPASSVG DLESSVTGSM INGWGSASEE 1380
DNISSGRSSV SSSDGSFFTD ADFAQAVAAA AEYAGLKVAR RQMQDAAGRR HFHASQCPRP 1440
TSPVSTDSNM SAAVIQKARP TKKQKHQPGH LRREAYTDDL PPPPVPPPAI KSPSVQSKAQ 1500
LEARPIMGPK LASIEARADR SSDRKGGSYK GREALDGRQV TDLRTSPGDP REAQEQPNEG 1560
KARGTKTAKR DLPPAKTHLI PEDILPYCRP TFPTSNNPRD PSSSSSMSSR GSGSRQREQA 1620
NVGRRNMAEM QVLGGFERGD ENNEELEETE S
1652Fasta Sequence
>O55005|Robo1|Rattus norvegicus(Rat)
MKWKHLPLLVMISLLTLSKKHLLLAQLIPDPEDLERGNDNGTPAPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESKVADVTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTFGWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTVTNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTLTLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLESGVLQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSKNTVTLLWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETFAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTTQGVDHKQVQRELGNVVLHLHNPTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEERPSAPPRSVTVSKNDGNGTAILVTWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGPGVKSEPQFIQLDSHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLSSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPATQPWLADTWPNTGNSHNDCSINCCTASNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQANLINNMNNGGGDSSEKHWKPPGQQKQEVAPIQYNIMEQNKLNKDYRANDTILPTIPYNHSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKAPKQGGMNWADLLPPPPAHPPPHSNSEEYSMSVDESYDQEMPCPVPPARMYLQQDELEEEEAERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVIQKARPTKKQKHQPGHLRREAYTDDLPPPPVPPPAIKSPSVQSKAQLEARPIMGPKLASIEARADRSSDRKGGSYKGREALDGRQVTDLRTSPGDPREAQEQPNEGKARGTKTAKRDLPPAKTHLIPEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNMAEMQVLGGFERGDENNEELEETES
|
| Keyword |
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-1015--Disulfide bond
KW-0325--Glycoprotein
KW-0393--Immunoglobulin domain
KW-0472--Membrane
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
|
| Interpro |
IPR003961--FN3_dom
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003598--Ig_sub2
|
| PROSITE |
PS50853--FN3
PS50835--IG_LIKE
|
| Pfam |
PF00041--fn3
PF07679--I-set
|
| Gene Ontology |
GO:0030424--C:axon
GO:0016021--C:integral component of membrane
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0008046--F:axon guidance receptor activity
GO:0007411--P:axon guidance
GO:0016199--P:axon midline choice point recognition
GO:0007417--P:central nervous system development
GO:0048814--P:regulation of dendrite morphogenesis
GO:0021510--P:spinal cord development
|
