dbPAF Protein Information
| Tag | Content |
|---|---|
| dbPAF ID | dbPAF-0001903 |
| Uniprot Accession | O55000; PP1RA_RAT; Q6MG09; |
| Genbank Protein ID | NP_075240.1; |
| Genbank Nucleotide ID | NM_022951.2; |
| Protein Name | Serine/threonine-protein phosphatase 1 regulatory subunit 10 |
| Protein Synonyms/Alias | MHC class I region proline-rich protein CAT53;Phosphatase 1 nuclear targeting subunit;Protein PNUTS; |
| Gene Name | Ppp1r10 |
| Gene Synonyms/Alias | Cat53;Pnuts; |
| Organism | Rattus norvegicus(Rat) |
| NCBI Taxa ID | 10116 |
| Functional Description (View all) |
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. |
| Phosphorylation Sites |
dbPAF PTMs: 5 |
| Sequence (Fasta) | MGSGPIDPKE LLKGLDSFLT RDGEVKSVDG IAKIFSLMKE ARKMVSRCTY LNIILQTRAP 60 EVLVKFIDVG GYKLLNSWLT YSKTTNNIPL LQQILLTLQH LPLTVDHLKQ NNTAKLVKQL 120 SKSSEDEELR KLASVLVSDW MAVIRSQSST QPAEKDKKKR KEEGKSRTTL PERPLTEVKA 180 ETRAEEAPEK KKEKPKSLRT TAPSHAKFRS TGLELDTPSL VPVKKNSSTV VVSDKYNLKP 240 IPLKRQSATA APGDAAPPAE KKYKPLNTTP NTTKEIKVKI IPPQPMEGLG FLDALNSAPV 300 PGIKIKKKKK VLSPTAAKPS PFEGKTSTEP STAKPSSPEP AAPAEPMDTD RPGTPVPAVE 360 VPELMDAASS EPGALDAKPV ESPGDPNQLT RKGRKRKTVT WPEEGKLREY FYFELDETER 420 VNVNKIKDFG EAAKREILSD RHAFETARRL SHDNMEEKVP WVCPRPLVLP SPLVIPGSNS 480 QERYIQAERE KGILQELFLN KESPHEPDPE PYEPIPPKLI PLDEECAMDE TPYVETLEPG 540 GSGGSPDGAG GSKLPPVLAN LMGSMGAGKS PQGPGGGGIN VQEILTSIMG SPNNHPSEEL 600 LKQPDYSDKL KQMLVPHGLL GPGPVANGFP PGGPGGPKGM QHFPPGPGGP MPGPHGGPGG 660 PVGPRLLGPP PPSRGGDPFW DGPGDPMRGG PMRGGPGPGP GPYHRGRGGR GGNEPPPPPP 720 FRGARGGRSG GGPPNGRGGP GGGGMVGGGG HRPHEGPGGS MGSGHRSHEG PGGSMGSGHR 780 SHEGPGHGGP HGHRPHDVPS HRGHDHRGPP PHEHRGHDGH GGGGHRGHDG GHSHGGDMSN 840 RPVCRHFMMK GNCRYENNCA FYHPGVNGPP LP 873 |
| Keyword | KW-0002--3D-structure |
| Interpro | IPR003617--TFIIS/CRSP70_N_sub |
| PROSITE | |
| Pfam | |
| Gene Ontology | GO:0000790--C:nuclear chromatin |