dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001897
Uniprot Accession O54975; XPP1_RAT;
Genbank Protein ID NP_571988.1;
Genbank Nucleotide ID NM_131913.1;
Protein Name Xaa-Pro aminopeptidase 1
Protein Synonyms/Alias Aminoacylproline aminopeptidase;Cytosolic aminopeptidase P;Soluble aminopeptidase P;sAmp;X-Pro aminopeptidase 1;X-prolyl aminopeptidase 1, soluble;
Gene Name Xpnpep1
Gene Synonyms/Alias App;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
128PLIIPTDYWKKMAKVPhosphoSitePlus22135298
Sequence
(Fasta)		MAPKVTSELL RQLRQAMRNS ECVAEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA 60
GTAIITEEHA AMWTDGRYFL QAAKQMDNNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD 120
PLIIPTDYWK KMAKVLRSAG HHLVPVKENL VDKIWTDRPE RPCKPLLTLG LDYTGISWKE 180
KVADLRLKMA ERSIVWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAIIGL ERIMLFIDGD 240
RIDAPGVKQH LLLDLGLEAE YKIQVLPYKS ILSELKTLCA DLSPREKVWV SDKASYAVSE 300
AIPKDHRCCM PYTPICIAKA VKNSAESAGM RRAHIKDAVA LCELFNWLEQ EVPKGGVTEI 360
SAADKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPIP ETNRTLSLDE VYLIDSGAQY 420
KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG 480
LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV 540
LVVPAKTKYN FNNRGSLTFE PLTLVPIQTK MIDVDALTDK ECDWLNSYHQ TCRDVIGKEL 600
QTQGRQEALE WLLRETEPIS RQH 624
Keyword

KW-0007--Acetylation
KW-0031--Aminopeptidase
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0378--Hydrolase
KW-0464--Manganese
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0645--Protease
KW-1185--Reference proteome
Interpro

IPR029149--Creatin/AminoP/Spt16_NTD
IPR028980--Creatinase/Aminopeptidase_P_N
IPR000587--Creatinase_N
IPR000994--Pept_M24_structural-domain
IPR032416--Peptidase_M24_C
IPR001131--Peptidase_M24B_aminopep-P_CS
PROSITE

PS00491--PROLINE_PEPTIDASE
Pfam

PF01321--Creatinase_N
PF00557--Peptidase_M24
PF16188--Peptidase_M24_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004177--F:aminopeptidase activity
GO:0030145--F:manganese ion binding
GO:0070006--F:metalloaminopeptidase activity
GO:0010815--P:bradykinin catabolic process
GO:0006508--P:proteolysis