| Tag |
Content |
| dbPAF ID |
dbPAF-0001895 |
| Uniprot Accession |
O54968; NF2L2_RAT; Q6P7C8;
|
| Genbank Protein ID |
NP_113977.1; XP_006234458.1;
|
| Genbank Nucleotide ID |
NM_031789.2; XM_006234396.2;
|
| Protein Name |
Nuclear factor erythroid 2-related factor 2 |
| Protein Synonyms/Alias |
|
| Gene Name |
Nfe2l2 |
| Gene Synonyms/Alias |
Nrf2; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity).Functional Description
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 1 |
Sequence
(Fasta) | MMDLELPPPG LQSQQDMDLI DILWRQDIDL GVSREVFDFS QRQKDYELEK QKKLEKERQE 60
QLQKEQEKAF FAQLQLDEET GEFLPIQPAQ HIQTDTSGSV SYSQVAHIPK QDALYFEDCM 120
QLLAETFPFV DDHEVSSPTF QSLALDIPSH VESSVFTTPD QAQSLDSSLE TAMTDLSSIQ 180
QDMEQVWQEL FSIPELQCLN TENKQQAETT TVPSPEATLT EMDSNYHFYS SIPSLEKEVD 240
SCSPHFLHGF EDSFSSILST DDASQLNSLD SNPTLNTDFG DEFYSAFLAE PSGGGSMPSS 300
AAISQSLSEL LGGPIEGCDL SLCKAFNQKH TEGTVEFNDS DSGISLNTSP SRASPEHSVE 360
SSIYGDPPPG FSDSEMEELD SAPGSVKQNG PKAQPTHSSG DTVQPLSPAQ GHSAAVHESQ 420
CENTTKKEVP VSPGHQKVPF TKDKHSSRLE AHLTRDELRA KALHIPFPVE KIINLPVDDF 480
NEMMSKEQFN EAQLALIRDI RRRGKNKVAA QNCRKRKLEN IVELEQDLGH LKDEREKLLR 540
EKGENDRNLH LLKRKLSTLY LEVFSMLRDE DGKPYSPSEY SLQQTRDGNV FLVPKSKKPD 600
TKKN
605Fasta Sequence
>O54968|Nfe2l2|Rattus norvegicus(Rat)
MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQKDYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQTDTSGSVSYSQVAHIPKQDALYFEDCMQLLAETFPFVDDHEVSSPTFQSLALDIPSHVESSVFTTPDQAQSLDSSLETAMTDLSSIQQDMEQVWQELFSIPELQCLNTENKQQAETTTVPSPEATLTEMDSNYHFYSSIPSLEKEVDSCSPHFLHGFEDSFSSILSTDDASQLNSLDSNPTLNTDFGDEFYSAFLAEPSGGGSMPSSAAISQSLSELLGGPIEGCDLSLCKAFNQKHTEGTVEFNDSDSGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPTHSSGDTVQPLSPAQGHSAAVHESQCENTTKKEVPVSPGHQKVPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRKLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN
|
| Keyword |
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
|
| Interpro |
IPR004827--bZIP
IPR004826--bZIP_Maf
IPR029845--Nrf2
IPR008917--TF_DNA-bd
|
| PROSITE |
PS50217--BZIP
PS00036--BZIP_BASIC
|
| Pfam |
PF03131--bZIP_Maf
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0001221--F:transcription cofactor binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0071498--P:cellular response to fluid shear stress
GO:0060548--P:negative regulation of cell death
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036091--P:positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated
|
