| Tag |
Content |
| dbPAF ID |
dbPAF-0001892 |
| Uniprot Accession |
O54963; REST_RAT; O54964;
|
| Genbank Protein ID |
NP_113976.1;
|
| Genbank Nucleotide ID |
NM_031788.1;
|
| Protein Name |
RE1-silencing transcription factor |
| Protein Synonyms/Alias |
Neural-restrictive silencer factor; |
| Gene Name |
Rest |
| Gene Synonyms/Alias |
Nrsf; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity).Functional Description
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MATQVMGQSS GGGSLFNNSG NMGMALPNDM YDLHDLSKAE LAAPQLIMLA NVALTGEVNG 60
SCCDYLVGEE RQMAELMPVG DNHFSDSEGE GLEESAELKG DPSGLDNMEL RSLELSVVEP 120
QPVFEASAAP EVYSSNKDPA PEAPVAEDKC KNLKAKPFRC KPCQYEAESE EQFVHHIRVH 180
SAKKFFVEES AEKQAKARES GASPSEEGEF SKGPIRCDRC GYNTNRYDHY TAHLKHHLRA 240
GDNERVYKCI ICTYTTVSEY HWRKHLRNHF PRKVYTCSKC NYFSTEKNNY VQHVRTHTGE 300
RPYKCELCPY SSSQKTHLTR HMRTHSGEKP FKCDQCNYVA SNQHEVTRHA RQVHNGPKPL 360
NCPHCDYKTA DRSNFKKHVE LHVNPRQFNC PVCDYAASKK CNLQYHFKSK HPTCPSKTMD 420
VSKVKLKKTK RREADLHRDA AAAATEQTDT EQAKTKGVDA SARRSERPVK GVGKDVPKEK 480
KPCSNASVVQ VTTRTRKSAV ETKAAEGKHT DGQTGNNAEK SSKAKKSKRK MDAEAHPSVE 540
PVTEGPVTKK KKTESKPKTS GEVPKGSRVE DRKADKQQSA SIKKGGKKTA LKTKTAKKGS 600
KLAPKWVGHT EPSSEMAQGG ESPVPALTQA VVTPSGSTQT ELSSPMDIAQ TEPAQMDVSQ 660
TGPPQVQRPL PVEPAQLEPS PPQEPPQVEP PACVEPPPPV EPPCPMEPAE MEPSPPMEPS 720
QVEPPPHLEP PLPMELPQVE LPPVEDCQKE LPPVEHAQTK VAQTGPTQVG AVQEEPLFCL 780
RATSSQANQK VISPKDRAKE KLSVLSEMAR QEQVLIEVGL VPVRDSQLLK ASKSAPDLPA 840
PPSPLPKGHL RREETPKDQE MFSDGEGNKV SPLEKGGTEE AGESRAELAA PMESTSALSS 900
EQSSNAPDGE TLHSECQADS TAVCEMEVDT EQKTDRVPLK DSAVEPVSPL NPRVDPEAAA 960
PAVVASPPIT LAESQEIDED EGIHSHDGSD LSDNMSEGSD DSGLHGARPA PQEATSKSGK 1020
EGLAVKVTEG EFVCIFCDRS FRKEKDYSKH LNRHLVNVYF LEEAAEEQE
Fasta Sequence
>O54963|Rest|Rattus norvegicus(Rat)
MATQVMGQSSGGGSLFNNSGNMGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNHFSDSEGEGLEESAELKGDPSGLDNMELRSLELSVVEPQPVFEASAAPEVYSSNKDPAPEAPVAEDKCKNLKAKPFRCKPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGASPSEEGEFSKGPIRCDRCGYNTNRYDHYTAHLKHHLRAGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCSKCNYFSTEKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKRREADLHRDAAAAATEQTDTEQAKTKGVDASARRSERPVKGVGKDVPKEKKPCSNASVVQVTTRTRKSAVETKAAEGKHTDGQTGNNAEKSSKAKKSKRKMDAEAHPSVEPVTEGPVTKKKKTESKPKTSGEVPKGSRVEDRKADKQQSASIKKGGKKTALKTKTAKKGSKLAPKWVGHTEPSSEMAQGGESPVPALTQAVVTPSGSTQTELSSPMDIAQTEPAQMDVSQTGPPQVQRPLPVEPAQLEPSPPQEPPQVEPPACVEPPPPVEPPCPMEPAEMEPSPPMEPSQVEPPPHLEPPLPMELPQVELPPVEDCQKELPPVEHAQTKVAQTGPTQVGAVQEEPLFCLRATSSQANQKVISPKDRAKEKLSVLSEMARQEQVLIEVGLVPVRDSQLLKASKSAPDLPAPPSPLPKGHLRREETPKDQEMFSDGEGNKVSPLEKGGTEEAGESRAELAAPMESTSALSSEQSSNAPDGETLHSECQADSTAVCEMEVDTEQKTDRVPLKDSAVEPVSPLNPRVDPEAAAPAVVASPPITLAESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPAPQEATSKSGKEGLAVKVTEGEFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQE
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
|
| PROSITE |
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
|
| Pfam |
|
| Gene Ontology |
GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0015271--F:outward rectifier potassium channel activity
GO:0032403--F:protein complex binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0060379--P:cardiac muscle cell myoblast differentiation
GO:0035690--P:cellular response to drug
GO:0071257--P:cellular response to electrical stimulus
GO:0071385--P:cellular response to glucocorticoid stimulus
GO:0070933--P:histone H4 deacetylation
GO:0043922--P:negative regulation by host of viral transcription
GO:0032348--P:negative regulation of aldosterone biosynthetic process
GO:2000798--P:negative regulation of amniotic stem cell differentiation
GO:0045955--P:negative regulation of calcium ion-dependent exocytosis
GO:0008285--P:negative regulation of cell proliferation
GO:2000065--P:negative regulation of cortisol biosynthetic process
GO:2000706--P:negative regulation of dense core granule biogenesis
GO:0010629--P:negative regulation of gene expression
GO:0046676--P:negative regulation of insulin secretion
GO:0050768--P:negative regulation of neurogenesis
GO:0045665--P:negative regulation of neuron differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0071805--P:potassium ion transmembrane transport
GO:0006351--P:transcription, DNA-templated
|
