dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001890
Uniprot Accession O54960; CAPON_RAT;
Genbank Protein ID NP_620277.1;
Genbank Nucleotide ID NM_138922.1;
Protein Name Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Protein Synonyms/Alias C-terminal PDZ ligand of neuronal nitric oxide synthase protein;Nitric oxide synthase 1 adaptor protein;
Gene Name Nos1ap
Gene Synonyms/Alias Capon;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
183DGQEDGESERNSDGSPhosphoSitePlus22135298
187DGESERNSDGSGDPGPhosphoSitePlus22135298
190SERNSDGSGDPGRQLPhosphoSitePlus22135298
262QEPMLAASPRMLLPSPhosphoSitePlus;curated22135298; 23712012; 21630457
365LKLSGQSTMGSQDSLPhosphoSitePlus22135298
368SGQSTMGSQDSLLEIPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
371STMGSQDSLLEITFRPhosphoSitePlus;UniProt;curated22135298; 22673903; 23984901
496QRQELGDSLDDEIAVPhosphoSitePlus22135298
Sequence
(Fasta)		MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI SFEAKYVGSL DVPRPNSRVE IVAAMRRIRY 60
EFKAKNIKKK KVSIMVSVDG VKVILKKKKK KKEWTWDESK MLVMQDPIYR IFYVSHDSQD 120
LKIFSYIARD GASNIFRCNV FKSKKKSQAM RIVRTVGQAF EVCHKLSLQH TQQNADGQED 180
GESERNSDGS GDPGRQLTGA ERVSTATAEE TDIDAVEVPL PGNDILEFSR GVTDLDAIGK 240
DGGSHIDTTV SPHPQEPMLA ASPRMLLPSS SSSKPPGLGT GTPLSTHHQM QLLQQLLQQQ 300
QQQTQVAVAQ VHLLKDQLAA EAAARLEAQA RVHQLLLQNK DMLQHISLLV KQVQELELKL 360
SGQSTMGSQD SLLEITFRSG ALPVLCESTT PKPEDLHSPL LGAGLADFAH PVGSPLGRRD 420
CLVKLECFRF LPAEDNQPMA QGEPLLGGLE LIKFRESGIA SEYESNTDES EERDSWSQEE 480
LPRLLNVLQR QELGDSLDDE IAV 504
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR011993--PH/PTB_dom
IPR006020--PTB/PI_dom
PROSITE

PS01179--PID
Pfam

PF00640--PID
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0050998--F:nitric-oxide synthase binding
GO:0030165--F:PDZ domain binding
GO:0002020--F:protease binding
GO:1901215--P:negative regulation of neuron death
GO:0031102--P:neuron projection regeneration
GO:0007269--P:neurotransmitter secretion
GO:2000170--P:positive regulation of peptidyl-cysteine S-nitrosylation
GO:0042981--P:regulation of apoptotic process
GO:0098901--P:regulation of cardiac muscle cell action potential
GO:1902514--P:regulation of generation of L-type calcium current
GO:1901841--P:regulation of high voltage-gated calcium channel activity
GO:0045428--P:regulation of nitric oxide biosynthetic process
GO:0050999--P:regulation of nitric-oxide synthase activity