dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001867
Uniprot Accession O54902; NRAM2_RAT; O35172;
Genbank Protein ID NP_037305.2;
Genbank Nucleotide ID NM_013173.2;
Protein Name Natural resistance-associated macrophage protein 2
Protein Synonyms/Alias
Gene Name Slc11a2
Gene Synonyms/Alias Dct1;Dmt1;Nramp2;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 May serve to import iron into the mitochondria (By similarity). Important in metal transport, in particular iron. Can also transport zinc, manganese, cobalt, cadmium, copper, nickel and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
21ASGDHGDSASLGAINcurated23712012; 21630457
23GDHGDSASLGAINPAcurated23712012; 21630457
Sequence
(Fasta)		MVLDPEEKIP DDGASGDHGD SASLGAINPA YSNSSLPHST GDSEEPFTTY FDEKIPIPEE 60
EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWVLLL ATIVGLLLQR 120
LAARLGVVTG LHLAEVCHRQ YPKVPRIILW LMVELAIIGS DMQEVIGSAI AINLLSAGRV 180
PLYGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL TFGYEYVTVK PSQSQVLRGM 240
FVPSCSGCHT PQVEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRANKQEVR EANKYFFIES 300
CIALFVSFII NVFVVSVFAE AFFEKTNEQV VEVCRNSSSP HADLFPNDNS TLAVDIYKGG 360
VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVILTRSIAI 420
IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSEF SNGIGWRIAG 480
GILVLLVCSI NMYFVVVYVQ ELGHVALYVV AAVVSVAYLG FVFYLGWQCL IALGLSFLDC 540
GRSYHLGLTA RPEIYLLNTV DAVSLVSR 569
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0406--Ion transport
KW-0408--Iron
KW-0410--Iron transport
KW-0472--Membrane
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR001046--NRAMP_fam
PROSITE
Pfam

PF01566--Nramp
Gene Ontology

GO:0045177--C:apical part of cell
GO:0016324--C:apical plasma membrane
GO:0045178--C:basal part of cell
GO:0031526--C:brush border membrane
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005769--C:early endosome
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005634--C:nucleus
GO:0070826--C:paraferritin complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0030904--C:retromer complex
GO:0005802--C:trans-Golgi network
GO:0046870--F:cadmium ion binding
GO:0015086--F:cadmium ion transmembrane transporter activity
GO:0050897--F:cobalt ion binding
GO:0015087--F:cobalt ion transmembrane transporter activity
GO:0005507--F:copper ion binding
GO:0005375--F:copper ion transmembrane transporter activity
GO:0015093--F:ferrous iron transmembrane transporter activity
GO:0015639--F:ferrous iron uptake transmembrane transporter activity
GO:0015078--F:hydrogen ion transmembrane transporter activity
GO:0005506--F:iron ion binding
GO:0005381--F:iron ion transmembrane transporter activity
GO:0015094--F:lead ion transmembrane transporter activity
GO:0030145--F:manganese ion binding
GO:0005384--F:manganese ion transmembrane transporter activity
GO:0016151--F:nickel cation binding
GO:0015099--F:nickel cation transmembrane transporter activity
GO:0015295--F:solute:proton symporter activity
GO:0015100--F:vanadium ion transmembrane transporter activity
GO:0008270--F:zinc ion binding
GO:0005385--F:zinc ion transmembrane transporter activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006878--P:cellular copper ion homeostasis
GO:0071456--P:cellular response to hypoxia
GO:0071281--P:cellular response to iron ion
GO:0034599--P:cellular response to oxidative stress
GO:0071356--P:cellular response to tumor necrosis factor
GO:1902861--P:copper ion import into cell
GO:0048813--P:dendrite morphogenesis
GO:0003032--P:detection of oxygen
GO:0048821--P:erythrocyte development
GO:0070627--P:ferrous iron import
GO:0015684--P:ferrous iron transport
GO:0006783--P:heme biosynthetic process
GO:0007611--P:learning or memory
GO:0060586--P:multicellular organismal iron ion homeostasis
GO:0046686--P:response to cadmium ion
GO:0001666--P:response to hypoxia
GO:0010039--P:response to iron ion
GO:0010288--P:response to lead ion
GO:0010042--P:response to manganese ion
GO:0000041--P:transition metal ion transport