dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001866
Uniprot Accession O54898; CAC1G_RAT; Q548R1;
Genbank Protein ID
Genbank Nucleotide ID
Protein Name Voltage-dependent T-type calcium channel subunit alpha-1G
Protein Synonyms/Alias Voltage-gated calcium channel subunit alpha Cav3.1;
Gene Name Cacna1g
Gene Synonyms/Alias
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
467VRAGLLSSPVARSGQdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;UniProt16452087; 16381945; 23193290; 22135298; 22673903
716HSRRRQRSLGPDAEPPhosphoSitePlus;UniProt22135298; 22673903
1033MSHPKSSSTGVGEALPhosphoSitePlus22135298
1118LSGEGQESQDEEESSPhosphoSitePlus;UniProt22135298; 22673903
1124ESQDEEESSEEDRASPhosphoSitePlus;UniProt22135298; 22673903
1125SQDEEESSEEDRASPPhosphoSitePlus;UniProt22135298; 22673903
1150LEREAKSSFDLPDTLPhosphoSitePlus22135298
2234DSTAASPSPKKDTLSPhosphoSitePlus22135298
Sequence
(Fasta)		MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG LPYPALAPVV 60
FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 120
DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 180
TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 240
CFLPENFSLP LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCSL 300
DYETYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 360
YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 420
STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAIGV RAGLLSSPVA RSGQEPQPSG 480
SCTRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRVPRASPE IQDRDANGSR RLMLPPPSTP 540
TPSGGPPRGA ESVHSFYHAD CHLEPVRCQA PPPRCPSEAS GRTVGSGKVY PTVHTSPPPE 600
ILKDKALVEV APSPGPPTLT SFNIPPGPFS SMHKLLETQS TGACHSSCKI SSPCSKADSG 660
ACGPDSCPYC ARTGAGEPES ADHVMPDSDS EAVYEFTQDA QHSDLRDPHS RRRQRSLGPD 720
AEPSSVLAFW RLICDTFRKI VDSKYFGRGI MIAILVNTLS MGIEYHEQPE ELTNALEISN 780
IVFTSLFALE MLLKLLVYGP FGYIKNPYNI FDGVIVVISV WEIVGQQGGG LSVLRTFRLM 840
RVLKLVRFLP ALQRQLVVLM KTMDNVATFC MLLMLFIFIF SILGMHLFGC KFASERDGDT 900
LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL YNGMASTSSW AALYFIALMT FGNYVLFNLL 960
VAILVEGFQA EGDATKSESE PDFFSPSVDG DGDRKKRLAL VALGEHAELR KSLLPPLIIH 1020
TAATPMSHPK SSSTGVGEAL GSGSRRTSSS GSAEPGAAHH EMKCPPSARS SPHSPWSAAS 1080
SWTSRRSSRN SLGRAPSLKR RSPSGERRSL LSGEGQESQD EEESSEEDRA SPAGSDHRHR 1140
GSLEREAKSS FDLPDTLQVP GLHRTASGRS SASEHQDCNG KSASGRLART LRTDDPQLDG 1200
DDDNDEGNLS KGERIQAWVR SRLPACCRER DSWSAYIFPP QSRFRLLCHR IITHKMFDHV 1260
VLVIIFLNCI TIAMERPKID PHSAERIFLT LSNYIFTAVF LAEMTVKVVA LGWCFGEQAY 1320
LRSSWNVLDG LLVLISVIDI LVSMVSDSGT KILGMLRVLR LLRTLRPLRV ISRAQGLKLV 1380
VETLMSSLKP IGNIVVICCA FFIIFGILGV QLFKGKFFVC QGEDTRNITN KSDCAEASYR 1440
WVRHKYNFDN LGQALMSLFV LASKDGWVDI MYDGLDAVGV DQQPIMNHNP WMLLYFISFL 1500
LIVAFFVLNM FVGVVVENFH KCRQHQEEEE ARRREEKRLR RLEKKRRSKE KQMAEAQCKP 1560
YYSDYSRFRL LVHHLCTSHY LDLFITGVIG LNVVTMAMEH YQQPQILDEA LKICNYIFTV 1620
IFVFESVFKL VAFGFRRFFQ DRWNQLDLAI VLLSIMGITL EEIEVNLSLP INPTIIRIMR 1680
VLRIARVLKL LKMAVGMRAL LHTVMQALPQ VGNLGLLFML LFFIFAALGV ELFGDLECDE 1740
THPCEGLGRH ATFRNFGMAF LTLFRVSTGD NWNGIMKDTL RDCDQESTCY NTVISPIYFV 1800
SFVLTAQFVL VNVVIAVLMK HLEESNKEAK EEAELEAELE LEMKTLSPQP HSPLGSPFLW 1860
PGVEGVNSTD SPKPGAPHTT AHIGAASGFS LEHPTMVPHP EEVPVPLGPD LLTVRKSGVS 1920
RTHSLPNDSY MCRNGSTAER SLGHRGWGLP KAQSGSILSV HSQPADTSCI LQLPKDVHYL 1980
LQPHGAPTWG AIPKLPPPGR SPLAQRPLRR QAAIRTDSLD VQGLGSREDL LSEVSGPSCP 2040
LTRSSSFWGG SSIQVQQRSG IQSKVSKHIR LPAPCPGLEP SWAKDPPETR SSLELDTELS 2100
WISGDLLPSS QEEPLFPRDL KKCYSVETQS CRRRPGFWLD EQRRHSIAVS CLDSGSQPRL 2160
CPSPSSLGGQ PLGGPGSRPK KKLSPPSISI DPPESQGSRP PCSPGVCLRR RAPASDSKDP 2220
SVSSPLDSTA ASPSPKKDTL SLSGLSSDPT DMDP 2255
Keyword

KW-0106--Calcium
KW-0107--Calcium channel
KW-0109--Calcium transport
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0851--Voltage-gated channel
Interpro

IPR027359--Channel_four-helix_dom
IPR005821--Ion_trans_dom
IPR005445--VDCC_T_a1
IPR030154--VDCC_T_a1G
PROSITE
Pfam

PF00520--Ion_trans
Gene Ontology

GO:0044297--C:cell body
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005891--C:voltage-gated calcium channel complex
GO:0008332--F:low voltage-gated calcium channel activity
GO:0014824--P:artery smooth muscle contraction
GO:0070509--P:calcium ion import
GO:0060402--P:calcium ion transport into cytosol
GO:0071549--P:cellular response to dexamethasone stimulus
GO:0034220--P:ion transmembrane transport
GO:0086010--P:membrane depolarization during action potential
GO:0045956--P:positive regulation of calcium ion-dependent exocytosis
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0051924--P:regulation of calcium ion transport