| Tag |
Content |
| dbPAF ID |
dbPAF-0001861 |
| Uniprot Accession |
O54874; MRCKA_RAT;
|
| Genbank Protein ID |
NP_446109.1;
|
| Genbank Nucleotide ID |
NM_053657.1;
|
| Protein Name |
Serine/threonine-protein kinase MRCK alpha |
| Protein Synonyms/Alias |
CDC42-binding protein kinase alpha;Myotonic dystrophy kinase-related CDC42-binding kinase alpha;MRCK alpha;Myotonic dystrophy protein kinase-like alpha; |
| Gene Name |
Cdc42bpa |
| Gene Synonyms/Alias |
Pk428; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.Functional Description
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MSGEVRLRQL EQFILDGPAQ TNGQCFSVET LLDILICLYD ECNNSPLRRE KNILEYLEWA 60
KPFTSKVKQM RLHREDFEIL KVIGRGAFGE VAVVKLKNAD KVFAMKILNK WEMLKRAETA 120
CFREERDVLV NGDSKWITTL HYAFQDDNNL YLVMDYYVGG DLLTLLSKFE DRLPEEMARF 180
YLAEMVIAID SVHQLHYVHR DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT 240
PDYISPEILQ AMEDGKGRYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER 300
FQFPTQVTDV SENAKDLIRR LICSREHRLG QNGIEDFKKH PFFSGIDWDN IRNCEAPYIP 360
EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV GFTYTSSCVL SDRSCLRVTA 420
GPTSLDLDVN VQRTLDNNLA TEAYERRIKR LEQEKLELTR KLQESTQTVQ ALQYSTVDGP 480
LTASKDLEIK SLKEEIEKLR KQVAEVNHLE QQLEEANSVR RELDDAFRQI KAFEKQIKTL 540
QQEREELNKE LVQASERLKN QSKELKDAHC QRKLAMQEFM EINERLTELH TQKQKLARHV 600
RDKEEEVDLV MQKAESLRQE LRRAERAKKE LEVHTEALIA EASKDRKLRE QSRHYSKQLE 660
NELEGLKQKQ ISYSPGICSI EHQQEITKLK TDLEKKSIFY EEEISKREGI HASEIKNLKK 720
ELHDSEGQQL ALNKEIMVLK DKLEKTRRES QSEREEFENE FKQQYEREKV LLTEENKKLT 780
SELDKLTSLY ESLSLRNQHL EEEVKDLADK KESVAHWEAQ ITEIIQWVSD EKDARGYLQA 840
LASKMTEELE ALRNSSLGTR ATDMPWKMRR FAKLDMSARL ELQSALDAEI RAKQAIQEEL 900
NKVKASNIIT ECKLKDSEKK NLELLSEIEQ LIKDTEELRS EKGVEHRDSQ HSFLAFLNTP 960
TDALDQFERS PSCTPAGKGR RIADSAPLPV HTPTLRKKGC PASAGFPPKR KTHQFFVKSF 1020
TAPTKCHQCT SLMVGLIRQG CSCEVCGFSC HITCVNKAPT TCPVPPEQTK GPLGIDPQKG 1080
VGTAYEGHVR IPKPAGVKKG WQRALAVVCD FKLFLYDIAE GKASQPSSVI SQVIDMRDEE 1140
FSVSSVLASD VIHASRKDIP CIFRVTASQL SAPSDKCSIL MLADSETERS KWVGVLSELH 1200
KVLKKNKFRD RSVYVPKEAY DSTLPLIKTT QAAAIIDHER VALGNEEGLF VVHVTKDEII 1260
RVGDNKKIHQ IELIPSDQLV AVISGRNRHV RLFPMSALDG RETDFYKLAE TKGCQTIAAG 1320
KVRHGALSCL CVAMKRQVLC YELFQSKTRH RKFKEIQVPC NVQWMAIFSE HLCVGFQSGF 1380
LRYPLNGEGS PCNMLHSNDH TLAFITHQPM DAICAVEISN KEYLLCFSSI GIYTDCQGRR 1440
SRQQELMWPA NPSSCCYNAP YLSIYSENAV DIFDVNSMEW IQTLPLKKVR PLNTEGSLNL 1500
LGLETIRLIY FKNKMAEGDE LVVPETSDNS RKQMVRNINN KRRYSFRVPE EERMQQRREM 1560
LRDPEMRNKL ISNPTNFNHI AHMGPGDGIQ ILKDLPMNPR PQESRTVFSG SVSIPSITKS 1620
RPEPGRSMSA SSGLSARSSA QNGSALKREF SGGSYNTKRQ PMPSPSEGSL SSGGVDQGSD 1680
APVRDYDGED SDSPRHSTAS NSSNLSSPPS PVSPRKTKSL SLESTDRGSW DP
1733Fasta Sequence
>O54874|Cdc42bpa|Rattus norvegicus(Rat)
MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKAFEKQIKTLQQEREELNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRAERAKKELEVHTEALIAEASKDRKLREQSRHYSKQLENELEGLKQKQISYSPGICSIEHQQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEIMVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGVEHRDSQHSFLAFLNTPTDALDQFERSPSCTPAGKGRRIADSAPLPVHTPTLRKKGCPASAGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTTCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPSSVISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSDKCSILMLADSETERSKWVGVLSELHKVLKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERVALGNEEGLFVVHVTKDEIIRVGDNKKIHQIELIPSDQLVAVISGRNRHVRLFPMSALDGRETDFYKLAETKGCQTIAAGKVRHGALSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFLRYPLNGEGSPCNMLHSNDHTLAFITHQPMDAICAVEISNKEYLLCFSSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSIYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDLPMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYNTKRQPMPSPSEGSLSSGGVDQGSDAPVRDYDGEDSDSPRHSTASNSSNLSSPPSPVSPRKTKSLSLESTDRGSWDP
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
|
| Interpro |
IPR000961--AGC-kinase_C
IPR001180--CNH_dom
IPR000095--CRIB_dom
IPR031597--KELK
IPR011009--Kinase-like_dom
IPR014930--Myotonic_dystrophy_kinase_coil
IPR002219--PE/DAG-bd
IPR011993--PH/PTB_dom
IPR001849--PH_domain
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
IPR026611--Ser/Thr_kinase_MRCK_alpha
|
| PROSITE |
PS51285--AGC_KINASE_CTER
PS50219--CNH
PS50108--CRIB
PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
|
| Pfam |
PF00130--C1_1
PF00780--CNH
PF08826--DMPK_coil
PF15796--KELK
PF00069--Pkinase
PF00433--Pkinase_C
|
| Gene Ontology |
GO:0042641--C:actomyosin
GO:0031252--C:cell leading edge
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0042802--F:identical protein binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0031532--P:actin cytoskeleton reorganization
GO:0031032--P:actomyosin structure organization
GO:0016477--P:cell migration
GO:0007010--P:cytoskeleton organization
GO:0035556--P:intracellular signal transduction
GO:0006468--P:protein phosphorylation
GO:0051056--P:regulation of small GTPase mediated signal transduction
|
