| Tag |
Content |
| dbPAF ID |
dbPAF-0001857 |
| Uniprot Accession |
O54861; SORT_RAT; O35389;
|
| Genbank Protein ID |
NP_113955.1;
|
| Genbank Nucleotide ID |
NM_031767.1;
|
| Protein Name |
Sortilin |
| Protein Synonyms/Alias |
Glycoprotein 110;Gp110;Neurotensin receptor 3;NTR3; |
| Gene Name |
Sort1 |
| Gene Synonyms/Alias |
|
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.Functional Description
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. |
Phosphorylation Sites
|
dbPAF PTMs: 4 |
Sequence
(Fasta) | MERPRGAADG LLRWPLGLLL LLQLLPPAAV GQDRLDAPPP PAPPLLRWAG PVGVSWGLRA 60
AAPGGPVPRA GRWRRGAPAE DQDCGRLPDF IAKLTNNTHQ HVFDDLSGSV SLSWVGDSTG 120
VILVLTTFQV PLVIVSFGQS KLYRSEDYGK NFKDITNLIN NTFIRTEFGM AIGPENSGKV 180
ILTAEVSGGS RGGRVFRSSD FAKNFVQTDL PFHPLTQMMY SPQNSDYLLA LSTENGLWVS 240
KNFGEKWEEI HKAVCLAKWG PNNIIFFTTH VNGSCKADLG ALELWRTSDL GKTFKTIGVK 300
IYSFGLGGRF LFASVMADKD TTRRIHVSTD QGDTWSMAQL PSVGQEQFYS ILAANDDMVF 360
MHVDEPGDTG FGTIFTSDDR GIVYSKSLDR HLYTTTGGET DFTNVTSLRG VYITSTLSED 420
NSIQSMITFD QGGRWEHLQK PENSKCDATA KNKNECSLHI HASYSISQKL NVPMAPLSEP 480
NAVGIVIAHG SVGDAISVMV PDVYISDDGG YSWAKMLEGP HYYTILDSGG IIVAIEHSNR 540
PINVIKFSTD EGQCWQSYVF SQEPVYFTGL ASEPGARSMN ISIWGFTESF LTRQWVSYTI 600
DFKDILERNC EENDYTTWLA HSTDPGDYKD GCILGYKEQF LRLRKSSVCQ NGRDYVVAKQ 660
PSICPCSLED FLCDFGYFRP ENASECVEQP ELKGHELEFC LYGKEEHLTT NGYRKIPGDR 720
CQGGMNPARE VKDLKKKCTS NFLNPKKQNS KSSSVPIILA IVGLMLVTVV AGVLIVKKYV 780
CGGRFLVHRY SVLQQHAEAD GVEALDTASH AKSGYHDDSD EDLLE
826Fasta Sequence
>O54861|Sort1|Rattus norvegicus(Rat)
MERPRGAADGLLRWPLGLLLLLQLLPPAAVGQDRLDAPPPPAPPLLRWAGPVGVSWGLRAAAPGGPVPRAGRWRRGAPAEDQDCGRLPDFIAKLTNNTHQHVFDDLSGSVSLSWVGDSTGVILVLTTFQVPLVIVSFGQSKLYRSEDYGKNFKDITNLINNTFIRTEFGMAIGPENSGKVILTAEVSGGSRGGRVFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGEKWEEIHKAVCLAKWGPNNIIFFTTHVNGSCKADLGALELWRTSDLGKTFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSTLSEDNSIQSMITFDQGGRWEHLQKPENSKCDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWAKMLEGPHYYTILDSGGIIVAIEHSNRPINVIKFSTDEGQCWQSYVFSQEPVYFTGLASEPGARSMNISIWGFTESFLTRQWVSYTIDFKDILERNCEENDYTTWLAHSTDPGDYKDGCILGYKEQFLRLRKSSVCQNGRDYVVAKQPSICPCSLEDFLCDFGYFRPENASECVEQPELKGHELEFCLYGKEEHLTTNGYRKIPGDRCQGGMNPAREVKDLKKKCTSNFLNPKKQNSKSSSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEADGVEALDTASHAKSGYHDDSDEDLLE
|
| Keyword |
KW-1003--Cell membrane
KW-0165--Cleavage on pair of basic residues
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0254--Endocytosis
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0458--Lysosome
KW-0472--Membrane
KW-0539--Nucleus
KW-0892--Osteogenesis
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR031777--Sortilin_C
IPR031778--Sortilin_N
IPR006581--VPS10
|
| PROSITE |
|
| Pfam |
PF15902--Sortilin-Vps10
PF15901--Sortilin_C
|
| Gene Ontology |
GO:0009986--C:cell surface
GO:0005905--C:coated pit
GO:0030425--C:dendrite
GO:0005769--C:early endosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0032580--C:Golgi cisterna membrane
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005765--C:lysosomal membrane
GO:0043025--C:neuronal cell body
GO:0031965--C:nuclear membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0030140--C:trans-Golgi network transport vesicle
GO:0016492--F:G-protein coupled neurotensin receptor activity
GO:0010465--F:nerve growth factor receptor activity
GO:0030379--F:neurotensin receptor activity, non-G-protein coupled
GO:0006897--P:endocytosis
GO:0008333--P:endosome to lysosome transport
GO:0032509--P:endosome transport via multivesicular body sorting pathway
GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors
GO:0046323--P:glucose import
GO:0006895--P:Golgi to endosome transport
GO:0006886--P:intracellular protein transport
GO:0007275--P:multicellular organismal development
GO:0014902--P:myotube differentiation
GO:0045599--P:negative regulation of fat cell differentiation
GO:0051005--P:negative regulation of lipoprotein lipase activity
GO:0048011--P:neurotrophin TRK receptor signaling pathway
GO:0001503--P:ossification
GO:0048227--P:plasma membrane to endosome transport
GO:1904037--P:positive regulation of epithelial cell apoptotic process
GO:0010468--P:regulation of gene expression
GO:0032868--P:response to insulin
GO:0016050--P:vesicle organization
|
