dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001856
Uniprot Accession O54857; O54857_RAT;
Genbank Protein ID NP_113794.1;
Genbank Nucleotide ID NM_031606.1;
Protein Name Phosphatase and tensin homolog, isoform CRA_a
Protein Synonyms/Alias
Gene Name Pten
Gene Synonyms/Alias PTEN/MMAC1;rCG_47874;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
113EDLDQWLSEDDNHVAPhosphoSitePlus22135298
319DKEYLVLTLTKNDLDPhosphoSitePlus22135298
380EPDHYRYSDTTDSDPPhosphoSitePlus;curated22135298; 22817900
383HYRYSDTTDSDPENEPhosphoSitePlus22135298
385RYSDTTDSDPENEPFPhosphoSitePlus22135298
Sequence
(Fasta)
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 60
HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 120
AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 180
LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKLMY 240
FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 300
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 360
SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI TKV 404
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR017361--Bifunc_PIno_P3_Pase/Pase_PTEN
IPR000008--C2_dom
IPR000340--Dual-sp_phosphatase_cat-dom
IPR029021--Prot-tyrosine_phosphatase-like
IPR014020--Tensin_C2-dom
IPR029023--Tensin_lipid_phosphatase_dom
IPR016130--Tyr_Pase_AS

PROSITE

PS51182--C2_TENSIN
PS51181--PPASE_TENSIN
PS00383--TYR_PHOSPHATASE_1

Pfam

PF00782--DSPc
PF10409--PTEN_C2

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0043197--C:dendritic spine
GO:0005739--C:mitochondrion
GO:0035749--C:myelin sheath adaxonal region
GO:0043005--C:neuron projection
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045211--C:postsynaptic membrane
GO:0043220--C:Schmidt-Lanterman incisure
GO:0051717--F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287--F:magnesium ion binding
GO:0030165--F:PDZ domain binding
GO:0016314--F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800--F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438--F:phosphatidylinositol-3-phosphatase activity
GO:0005161--F:platelet-derived growth factor receptor binding
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0004725--F:protein tyrosine phosphatase activity
GO:0008138--F:protein tyrosine/serine/threonine phosphatase activity
GO:0007092--P:activation of APC-Cdc20 complex activity
GO:0030534--P:adult behavior
GO:0007568--P:aging
GO:0001525--P:angiogenesis
GO:0060070--P:canonical Wnt signaling pathway
GO:0048738--P:cardiac muscle tissue development
GO:0071456--P:cellular response to hypoxia
GO:0032286--P:central nervous system myelin maintenance
GO:0021955--P:central nervous system neuron axonogenesis
GO:0060997--P:dendritic spine morphogenesis
GO:0021542--P:dentate gyrus development
GO:0043542--P:endothelial cell migration
GO:0048853--P:forebrain morphogenesis
GO:0046855--P:inositol phosphate dephosphorylation
GO:0045475--P:locomotor rhythm
GO:0060292--P:long term synaptic depression
GO:0060291--P:long-term synaptic potentiation
GO:0060179--P:male mating behavior
GO:0042711--P:maternal behavior
GO:0007613--P:memory
GO:0033555--P:multicellular organismal response to stress
GO:0043066--P:negative regulation of apoptotic process
GO:0050771--P:negative regulation of axonogenesis
GO:0090344--P:negative regulation of cell aging
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:0045792--P:negative regulation of cell size
GO:0031658--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0061002--P:negative regulation of dendritic spine morphogenesis
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0090394--P:negative regulation of excitatory postsynaptic potential
GO:0051895--P:negative regulation of focal adhesion assembly
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
GO:0031642--P:negative regulation of myelination
GO:0046621--P:negative regulation of organ growth
GO:0050765--P:negative regulation of phagocytosis
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0090071--P:negative regulation of ribosome biogenesis
GO:2000808--P:negative regulation of synaptic vesicle clustering
GO:0031175--P:neuron projection development
GO:0007270--P:neuron-neuron synaptic transmission
GO:0046856--P:phosphatidylinositol dephosphorylation
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0043065--P:positive regulation of apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0008284--P:positive regulation of cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:2000463--P:positive regulation of excitatory postsynaptic potential
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107--P:postsynaptic density assembly
GO:0060134--P:prepulse inhibition
GO:0097105--P:presynaptic membrane assembly
GO:0060736--P:prostate gland growth
GO:0043491--P:protein kinase B signaling
GO:0050821--P:protein stabilization
GO:0048679--P:regulation of axon regeneration
GO:0002902--P:regulation of B cell apoptotic process
GO:0033032--P:regulation of myeloid cell apoptotic process
GO:0032228--P:regulation of synaptic transmission, GABAergic
GO:0046685--P:response to arsenic-containing substance
GO:0033198--P:response to ATP
GO:0042493--P:response to drug
GO:0032355--P:response to estradiol
GO:0045471--P:response to ethanol
GO:0009749--P:response to glucose
GO:0010035--P:response to inorganic substance
GO:0007584--P:response to nutrient
GO:0014070--P:response to organic cyclic compound
GO:0010033--P:response to organic substance
GO:0010043--P:response to zinc ion
GO:0060024--P:rhythmic synaptic transmission
GO:0035176--P:social behavior
GO:0060074--P:synapse maturation