Tag |
Content |
dbPAF ID |
dbPAF-0001856 |
Uniprot Accession |
O54857; O54857_RAT; |
Genbank Protein ID |
NP_113794.1; |
Genbank Nucleotide ID |
NM_031606.1; |
Protein Name |
Phosphatase and tensin homolog, isoform CRA_a |
Protein Synonyms/Alias |
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Gene Name |
Pten |
Gene Synonyms/Alias |
PTEN/MMAC1;rCG_47874; |
Organism |
Rattus norvegicus(Rat) |
NCBI Taxa ID |
10116 |
Functional Description (View all) |
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Phosphorylation Sites
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dbPAF PTMs: 5 Position | Peptides | Source | References ( PMIDs ) |
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113 | EDLDQWLSEDDNHVA | PhosphoSitePlus | 22135298 | 319 | DKEYLVLTLTKNDLD | PhosphoSitePlus | 22135298 | 380 | EPDHYRYSDTTDSDP | PhosphoSitePlus;curated | 22135298; 22817900 | 383 | HYRYSDTTDSDPENE | PhosphoSitePlus | 22135298 | 385 | RYSDTTDSDPENEPF | PhosphoSitePlus | 22135298 |
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Sequence (Fasta) | MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 60 HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 120 AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 180 LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKLMY 240 FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 300 DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 360 SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI TKV
404Fasta Sequence
>O54857|Pten|Rattus norvegicus(Rat) MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV
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Keyword |
KW-0002--3D-structure KW-0181--Complete proteome KW-1267--Proteomics identification KW-1185--Reference proteome
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Interpro |
IPR017361--Bifunc_PIno_P3_Pase/Pase_PTEN IPR000008--C2_dom IPR000340--Dual-sp_phosphatase_cat-dom IPR029021--Prot-tyrosine_phosphatase-like IPR014020--Tensin_C2-dom IPR029023--Tensin_lipid_phosphatase_dom IPR016130--Tyr_Pase_AS
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PROSITE |
PS51182--C2_TENSIN PS51181--PPASE_TENSIN PS00383--TYR_PHOSPHATASE_1
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Pfam |
PF00782--DSPc PF10409--PTEN_C2
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Gene Ontology |
GO:0016324--C:apical plasma membrane GO:0005737--C:cytoplasm GO:0009898--C:cytoplasmic side of plasma membrane GO:0043197--C:dendritic spine GO:0005739--C:mitochondrion GO:0035749--C:myelin sheath adaxonal region GO:0043005--C:neuron projection GO:0005654--C:nucleoplasm GO:0005634--C:nucleus GO:0045211--C:postsynaptic membrane GO:0043220--C:Schmidt-Lanterman incisure GO:0051717--F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0000287--F:magnesium ion binding GO:0030165--F:PDZ domain binding GO:0016314--F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0051800--F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity GO:0004438--F:phosphatidylinositol-3-phosphatase activity GO:0005161--F:platelet-derived growth factor receptor binding GO:0004722--F:protein serine/threonine phosphatase activity GO:0004725--F:protein tyrosine phosphatase activity GO:0008138--F:protein tyrosine/serine/threonine phosphatase activity GO:0007092--P:activation of APC-Cdc20 complex activity GO:0030534--P:adult behavior GO:0007568--P:aging GO:0001525--P:angiogenesis GO:0060070--P:canonical Wnt signaling pathway GO:0048738--P:cardiac muscle tissue development GO:0071456--P:cellular response to hypoxia GO:0032286--P:central nervous system myelin maintenance GO:0021955--P:central nervous system neuron axonogenesis GO:0060997--P:dendritic spine morphogenesis GO:0021542--P:dentate gyrus development GO:0043542--P:endothelial cell migration GO:0048853--P:forebrain morphogenesis GO:0046855--P:inositol phosphate dephosphorylation GO:0045475--P:locomotor rhythm GO:0060292--P:long term synaptic depression GO:0060291--P:long-term synaptic potentiation GO:0060179--P:male mating behavior GO:0042711--P:maternal behavior GO:0007613--P:memory GO:0033555--P:multicellular organismal response to stress GO:0043066--P:negative regulation of apoptotic process GO:0050771--P:negative regulation of axonogenesis GO:0090344--P:negative regulation of cell aging GO:0030336--P:negative regulation of cell migration GO:0008285--P:negative regulation of cell proliferation GO:0045792--P:negative regulation of cell size GO:0031658--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0061002--P:negative regulation of dendritic spine morphogenesis GO:0050680--P:negative regulation of epithelial cell proliferation GO:0090394--P:negative regulation of excitatory postsynaptic potential GO:0051895--P:negative regulation of focal adhesion assembly GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle GO:0031642--P:negative regulation of myelination GO:0046621--P:negative regulation of organ growth GO:0050765--P:negative regulation of phagocytosis GO:0051898--P:negative regulation of protein kinase B signaling GO:0090071--P:negative regulation of ribosome biogenesis GO:2000808--P:negative regulation of synaptic vesicle clustering GO:0031175--P:neuron projection development GO:0007270--P:neuron-neuron synaptic transmission GO:0046856--P:phosphatidylinositol dephosphorylation GO:0048008--P:platelet-derived growth factor receptor signaling pathway GO:0043065--P:positive regulation of apoptotic process GO:2001235--P:positive regulation of apoptotic signaling pathway GO:0008284--P:positive regulation of cell proliferation GO:0070374--P:positive regulation of ERK1 and ERK2 cascade GO:2000463--P:positive regulation of excitatory postsynaptic potential GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity GO:0097107--P:postsynaptic density assembly GO:0060134--P:prepulse inhibition GO:0097105--P:presynaptic membrane assembly GO:0060736--P:prostate gland growth GO:0043491--P:protein kinase B signaling GO:0050821--P:protein stabilization GO:0048679--P:regulation of axon regeneration GO:0002902--P:regulation of B cell apoptotic process GO:0033032--P:regulation of myeloid cell apoptotic process GO:0032228--P:regulation of synaptic transmission, GABAergic GO:0046685--P:response to arsenic-containing substance GO:0033198--P:response to ATP GO:0042493--P:response to drug GO:0032355--P:response to estradiol GO:0045471--P:response to ethanol GO:0009749--P:response to glucose GO:0010035--P:response to inorganic substance GO:0007584--P:response to nutrient GO:0014070--P:response to organic cyclic compound GO:0010033--P:response to organic substance GO:0010043--P:response to zinc ion GO:0060024--P:rhythmic synaptic transmission GO:0035176--P:social behavior GO:0060074--P:synapse maturation
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