dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001855
Uniprot Accession O54852; KCNH7_RAT;
Genbank Protein ID NP_571987.1;
Genbank Nucleotide ID NM_131912.1;
Protein Name Potassium voltage-gated channel subfamily H member 7
Protein Synonyms/Alias Ether-a-go-go-related gene potassium channel 3;ERG-3;Eag-related protein 3;Ether-a-go-go-related protein 3;Voltage-gated potassium channel subunit Kv11.3;
Gene Name Kcnh7
Gene Synonyms/Alias Erg3;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)
Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
174VLTYRKQSLPQEDPDPhosphoSitePlus;UniProt22135298; 22673903
319SSLLGSTSDSNLNKYPhosphoSitePlus;UniProt22135298; 22673903
891KLRRRRLSFESEGDKPhosphoSitePlus;UniProt22135298; 22673903
894RRRLSFESEGDKDFSPhosphoSitePlus;UniProt22135298; 22673903
Sequence
(Fasta)
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE MTGFSRPDVM 60
QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH KNGSTFICNT HIIPVKNQEG 120
VAMMFIINFE YVTDEDNAAS PERVNPILPV KSVNRKLFGF KFPGLRVLTY RKQSLPQEDP 180
DVVVIDSSKH SDDSVAMKHF KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP 240
KRQWDRLYPD MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFNVHPKNIF RDRHASEDNG 300
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS PPSSDKTIIA 360
PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI LHYSPFKAVW DWLILLLVIY 420
TAIFTPYSAA FLLNDREEQK RRECGYSCSP LNVVDLIVDI MFIIDILINF RTTYVNQNEE 480
VVSDPAKIAV HYFKGWFLID MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK 540
LDRYSEYGAA VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN 600
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI GSLMYASIFG 660
NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL EEYFQHAWTY TNGIDMNMVL 720
KGFPECLQAD ICLHLNQTLL QNCKAFRGAS KGCLRALAMK FKTTHAPPGD TLVHCGDVLT 780
ALYFLSRGSI EILKDDIVVA ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED 840
LLEVLDMYPE FSDHFLTNLE LTFNLRHESA KSQSINDSEG DTCKLRRRRL SFESEGDKDF 900
SKENSANDAD DSTDTIRRYQ SSKKHFEEKK SRSSSFISSI DDEQKPLFLG TVDSTPRMVK 960
ASRHHGEEAA PPSGRIHTDK RSHSCKDITD THSWEREHAR AQPEECSPSG LQRAAWGISE 1020
TESDLTYGEV EQRLDLLQEQ LNRLESQMTT DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ 1080
RPILRLLRTS HPRASIKTDR SFSPSSQCPE FLDLEKSKLK SKESLSSGKR LNTASEDNLT 1140
SLLKQDSDAS SELDPRQRKS YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK 1196
Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0407--Ion channel
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0630--Potassium
KW-0631--Potassium channel
KW-0633--Potassium transport
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0851--Voltage-gated channel

Interpro

IPR018490--cNMP-bd-like
IPR000595--cNMP-bd_dom
IPR005821--Ion_trans_dom
IPR003938--K_chnl_volt-dep_EAG/ELK/ERG
IPR003967--K_chnl_volt-dep_ERG
IPR001610--PAC
IPR000014--PAS
IPR014710--RmlC-like_jellyroll

PROSITE

PS50042--CNMP_BINDING_3

Pfam

PF00027--cNMP_binding
PF00520--Ion_trans
PF13426--PAS_9

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005242--F:inward rectifier potassium channel activity
GO:0005267--F:potassium channel activity
GO:0005249--F:voltage-gated potassium channel activity
GO:0007623--P:circadian rhythm
GO:0071805--P:potassium ion transmembrane transport
GO:0006813--P:potassium ion transport
GO:0051291--P:protein heterooligomerization
GO:0042391--P:regulation of membrane potential