| Tag |
Content |
| dbPAF ID |
dbPAF-0001852 |
| Uniprot Accession |
O54835; SMAD9_RAT;
|
| Genbank Protein ID |
NP_620227.1;
|
| Genbank Nucleotide ID |
NM_138872.1;
|
| Protein Name |
Mothers against decapentaplegic homolog 9 |
| Protein Synonyms/Alias |
|
| Gene Name |
Smad9 |
| Gene Synonyms/Alias |
Madh8;Madh9;Smad8; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD) (By similarity). Has been shown to be activated by activin type I receptor-like kinase-2 (ALK-2) which stimulates heteromerization between SMAD9 and SMAD4. ALK-2 binds TGF-beta, activin and BMP.Functional Description
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD) (By similarity). Has been shown to be activated by activin type I receptor-like kinase-2 (ALK-2) which stimulates heteromerization between SMAD9 and SMAD4. ALK-2 binds TGF-beta, activin and BMP. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MHPSTPISSL FSFTSPAVKR LLGWKQGDEE EKWAEKAVDS LVKKLKKKKG AMDELERALS 60
CPGQPSKCVT IPRSLDGRLQ VSHRKGLPHV IYCRVWRWPD LQSHHELKPL ECCEFPFGSK 120
QKEVCINPYH YRRVETPVLP PVLVPRHSEY NPQLSLLAKF RSASLHSEPL MPHNATYPDS 180
FQQSLGPAPP SSPGHVFPQS PCPTSYPQSP GSPSESDSPY QHSDFRPVCY EEPLHWCSVA 240
YYELNNRVGE TFQASSRSVL IDGFTDPSNN RNRFCLGLLS NVNRNSTIEN TRRHIGKGVH 300
LYYVGGEVYA ECVSDSSIFV QSRNCNYQHG FHPATVCKIP SGCSLKVFNN QLFAQLLAQL 360
LAQSVHHGFE VVYELTKMCT IRMSFVKGWG AEYHRQDVTS TPCWIEIHLH GPLQWLDKVL 420
TQMGSPHNPI SSVS
435Fasta Sequence
>O54835|Smad9|Rattus norvegicus(Rat)
MHPSTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQSLGPAPPSSPGHVFPQSPCPTSYPQSPGSPSESDSPYQHSDFRPVCYEEPLHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
|
| Keyword |
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
|
| Interpro |
IPR013790--Dwarfin
IPR003619--MAD_homology1_Dwarfin-type
IPR013019--MAD_homology_MH1
IPR017855--SMAD_dom-like
IPR001132--SMAD_dom_Dwarfin-type
IPR008984--SMAD_FHA_domain
|
| PROSITE |
PS51075--MH1
PS51076--MH2
|
| Pfam |
PF03165--MH1
PF03166--MH2
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001880--P:Mullerian duct regression
GO:0045597--P:positive regulation of cell differentiation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0001666--P:response to hypoxia
GO:0006351--P:transcription, DNA-templated
GO:0007179--P:transforming growth factor beta receptor signaling pathway
|
