| Tag |
Content |
| dbPAF ID |
dbPAF-0001823 |
| Uniprot Accession |
O54735; PDE5A_RAT;
|
| Genbank Protein ID |
NP_598268.1;
|
| Genbank Nucleotide ID |
NM_133584.1;
|
| Protein Name |
cGMP-specific 3',5'-cyclic phosphodiesterase |
| Protein Synonyms/Alias |
cGMP-binding cGMP-specific phosphodiesterase;CGB-PDE; |
| Gene Name |
Pde5a |
| Gene Synonyms/Alias |
Pde5; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.Functional Description
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 60 | GAPARKISASEFDRP | PhosphoSitePlus | 22135298 |
|
Sequence
(Fasta) | MLPFGDKTRD MVNAWFSERV HNIPVCKEGI RAHTESCSCS LPQSPHADNT TPGAPARKIS 60
ASEFDRPLRP IVVKDSEGTV SFLSDSGKKE QMPLTSPRFD SDEGDQCSRL LELVKDISSH 120
LDVTALCHKI FLHIHGLISA DRYSLFLVCE DSSKDKFLVS RLFDVAEGST LEEASNNCIR 180
LEWNKGIVGH VAAFGEPLNI KDAYEDPRFN AEVDQITGYK TQSILCMPIK NHREEVVGVA 240
QAINKKSGNG GTFTEKDEKD FAAYLAFCGI VLHNAQLYET SLLENKRNQV LLDLASLIFE 300
EQQSLEVILK KIAATIISFM QVQKCTIFIV DEDCPDSFSR VFQMEWEEVG KSSEPLTREH 360
DANKINYMYA QYVKNTMEPL NIPDVTKDNR FPWTNENMGH INTHCIRSLL CTPIKNGKKN 420
KVIGVCQLVN KMEEKTGKIK AFNQNDEQFL EAFVIFCGLG IQNTQMYEAV ERAMAKQMVT 480
LEVLSYHASA AEEETRELQA LAAAVVPSAQ TLKITDFSFS DFELSDLETA LCTIRMFTDL 540
NLVQNFQMKH EVLCRWILSV KKNYRKNVAY HNWRHAFNTA QCMFAALKAG KIQNKLTDLE 600
TLALLIAALS HDLDHRGVNN SYIQRSEHPL AQLYCHSTME HHHFDQCLMV LNSPGNQILS 660
GLSIEEYKTT LKIIKQAILA TDLALYIKRR GEFFELIRKN EFSFEDPLQK ELFLAMLMTA 720
CDLSAITKPW PIQQRIAELV AAEFFDQGDR ERKELNMEPA DLMNREKKNK IPSMQVGFID 780
AICLQLYEAL THVSEDCLPL LDGCRKNRQK WQALADQQEK TLLNGESGQA KRD
834Fasta Sequence
>O54735|Pde5a|Rattus norvegicus(Rat)
MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREHDANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD
|
| Keyword |
KW-0021--Allosteric enzyme
KW-0025--Alternative splicing
KW-0140--cGMP
KW-0142--cGMP-binding
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
|
| Interpro |
IPR003018--GAF
IPR029016--GAF_dom-like
IPR003607--HD/PDEase_dom
IPR023088--PDEase
IPR002073--PDEase_catalytic_dom
IPR023174--PDEase_CS
|
| PROSITE |
PS00126--PDEASE_I
|
| Pfam |
PF01590--GAF
PF00233--PDEase_I
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0047555--F:3',5'-cyclic-GMP phosphodiesterase activity
GO:0030553--F:cGMP binding
GO:0046872--F:metal ion binding
GO:0046069--P:cGMP catabolic process
GO:0007399--P:nervous system development
GO:0043065--P:positive regulation of apoptotic process
GO:0002678--P:positive regulation of chronic inflammatory response
GO:0045907--P:positive regulation of vasoconstriction
GO:0002026--P:regulation of the force of heart contraction
GO:0001666--P:response to hypoxia
GO:0032496--P:response to lipopolysaccharide
GO:0033574--P:response to testosterone
GO:0007614--P:short-term memory
GO:0007165--P:signal transduction
GO:0042311--P:vasodilation
|
