| Tag |
Content |
| dbPAF ID |
dbPAF-0001818 |
| Uniprot Accession |
O54701; NCKX2_RAT; O54706;
|
| Genbank Protein ID |
NP_113931.1;
|
| Genbank Nucleotide ID |
NM_031743.2;
|
| Protein Name |
Sodium/potassium/calcium exchanger 2 |
| Protein Synonyms/Alias |
Na(+)/K(+)/Ca(2+)-exchange protein 2;Retinal cone Na-Ca+K exchanger;Solute carrier family 24 member 2; |
| Gene Name |
Slc24a2 |
| Gene Synonyms/Alias |
Nckx2; |
| Organism |
Rattus norvegicus(Rat) |
| NCBI Taxa ID |
10116 |
Functional Description
(View all) |
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).Functional Description
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). |
Phosphorylation Sites
|
dbPAF PTMs: 7 |
Sequence
(Fasta) | MDLHQSATVR LLQEWCSHES PSGCRRHYNT RKKLKLIRVI GLVMGLVAVS TVPFSISAFT 60
ETYSQNNRGE ASDVTGPRAA PGHRQRTLLD LNDKIRDYTP QPPASQEDRS ENGTDHAQGD 120
YPKDVFSLEE RRKGAIILHV IGMIYMFIAL AIVCDEFFVP SLTVITEKLG ISDDVAGATF 180
MAAGGSAPEL FTSLIGVFIA HSNVGIGTIV GSAVFNILFV IGMCALFSRE ILNLTWWPLF 240
RDVSFYIVDL IMLIIFFLDN VIMWWESLLL LTAYFAYVVF MKFNVQVERW VKQMINRNKV 300
VKVTVSEAQA KASTAGDKEE PTLPNKPRLQ RGGSSASLHN SLMRNSIFQL MIHTLDPLAE 360
ELGSYGKLKY YDTMTEEGRF REKASILHKI AKKKCQVDEN ERQNGAANHV DYAAEKIELP 420
NSTSTEVEMT PSSEASEPVQ NGNLSHSIEA ADAPQATETA EEDDDQPLSL SWPSNTRKQI 480
TFLIVLPIVF PLWITLPDVR KPASKKFFPI TFFGSITWIA VFSYLMVWWA HQVGETIGIS 540
EEIMGLTILA AGTSIPDLIT SVIVARKGLG DMAVSSSVGS NIFDITVGLP LPWLLYTIIH 600
RFKPVTVSSN GLFCAIVLLF IMLIFVILSI ALCKWRMNKI LGFIMFGLYF AFLVVSVLLE 660
DKVLECPVSI
671Fasta Sequence
>O54701|Slc24a2|Rattus norvegicus(Rat)
MDLHQSATVRLLQEWCSHESPSGCRRHYNTRKKLKLIRVIGLVMGLVAVSTVPFSISAFTETYSQNNRGEASDVTGPRAAPGHRQRTLLDLNDKIRDYTPQPPASQEDRSENGTDHAQGDYPKDVFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFRDVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFAYVVFMKFNVQVERWVKQMINRNKVVKVTVSEAQAKASTAGDKEEPTLPNKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCQVDENERQNGAANHVDYAAEKIELPNSTSTEVEMTPSSEASEPVQNGNLSHSIEAADAPQATETAEEDDDQPLSLSWPSNTRKQITFLIVLPIVFPLWITLPDVRKPASKKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFKPVTVSSNGLFCAIVLLFIMLIFVILSIALCKWRMNKILGFIMFGLYFAFLVVSVLLEDKVLECPVSI
|
| Keyword |
KW-0025--Alternative splicing
KW-0050--Antiport
KW-0106--Calcium
KW-0109--Calcium transport
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0406--Ion transport
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0630--Potassium
KW-0633--Potassium transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0716--Sensory transduction
KW-0915--Sodium
KW-0739--Sodium transport
KW-0769--Symport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
KW-0844--Vision
|
| Interpro |
IPR004481--K/Na/Ca-exchanger
IPR004837--NaCa_Exmemb
|
| PROSITE |
|
| Pfam |
PF01699--Na_Ca_ex
|
| Gene Ontology |
GO:0005887--C:integral component of plasma membrane
GO:0031226--C:intrinsic component of plasma membrane
GO:0046870--F:cadmium ion binding
GO:0005262--F:calcium channel activity
GO:0005509--F:calcium ion binding
GO:0008273--F:calcium, potassium:sodium antiporter activity
GO:0030145--F:manganese ion binding
GO:0016151--F:nickel cation binding
GO:0030955--F:potassium ion binding
GO:0046983--F:protein dimerization activity
GO:0031402--F:sodium ion binding
GO:0015293--F:symporter activity
GO:0070588--P:calcium ion transmembrane transport
GO:0006874--P:cellular calcium ion homeostasis
GO:0007612--P:learning
GO:0060292--P:long term synaptic depression
GO:0060291--P:long-term synaptic potentiation
GO:0007613--P:memory
GO:0050896--P:response to stimulus
GO:0035725--P:sodium ion transmembrane transport
GO:0007601--P:visual perception
|
