dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001817
Uniprot Accession O54698; S29A1_RAT;
Genbank Protein ID NP_113872.1; XP_006244622.1; XP_006244623.1; XP_006244624.1; XP_006244625.1; XP_008765101.1;
Genbank Nucleotide ID NM_031684.2; XM_006244560.1; XM_006244561.2; XM_006244562.2; XM_006244563.2; XM_008766879.1;
Protein Name Equilibrative nucleoside transporter 1
Protein Synonyms/Alias Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter;Equilibrative NBMPR-sensitive nucleoside transporter;Nucleoside transporter, es-type;Solute carrier family 29 member 1;
Gene Name Slc29a1
Gene Synonyms/Alias Ent1;
Organism Rattus norvegicus(Rat)
NCBI Taxa ID 10116
Functional Description
(View all)		 Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs).
Phosphorylation Sites
 dbPAF PTMs: 1
PositionPeptidesSourceReferences ( PMIDs )
254ETKLDLISEGEEPRGPhosphoSitePlus;UniProt22135298; 22673903
Sequence
(Fasta)		MTTSHQPQDR YKAVWLIFFV LGLGTLLPWN FFITATQYFT SRLNTSQNIS LVTNQSCEST 60
EALADPSVSL PARSSLSAIF NNVMTLCAML PLLIFTCLNS FLHQKVSQSL RILGSLLAIL 120
LVFLVTATLV KVQMDALSFF IITMIKIVLI NSFGAILQAS LFGLAGVLPA NYTAPIMSGQ 180
GLAGFFTSVA MICAVASGSK LSESAFGYFI TACAVVILAI LCYLALPWME FYRHYLQLNL 240
AGPAEQETKL DLISEGEEPR GGREESGVPG PNSLPANRNQ SIKAILKSIW VLALSVCFIF 300
TVTIGLFPAV TAEVESSIAG TSPWKNCYFI PVACFLNFNV FDWLGRSLTA ICMWPGQDSR 360
WLPVLVACRV VFIPLLMLCN VKQHHYLPSL FKHDVWFITF MAAFAFSNGY LASLCMCFGP 420
KKVKPAEAET AGNIMSFFLC LGLALGAVLS FLLRALV 458
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR030195--ENT1
IPR002259--Eqnu_transpt
IPR020846--MFS_dom
PROSITE
Pfam

PF01733--Nucleoside_tran
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005337--F:nucleoside transmembrane transporter activity
GO:0071333--P:cellular response to glucose stimulus
GO:0071456--P:cellular response to hypoxia
GO:0060079--P:excitatory postsynaptic potential
GO:0007595--P:lactation
GO:1901642--P:nucleoside transmembrane transport
GO:0015858--P:nucleoside transport
GO:0030431--P:sleep
GO:0015862--P:uridine transport