dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001811
Uniprot Accession O46106; NOI_DROME;
Genbank Protein ID NP_477114.1;
Genbank Nucleotide ID NM_057766.5;
Protein Name Splicing factor 3A subunit 3
Protein Synonyms/Alias Protein noisette;
Gene Name noi
Gene Synonyms/Alias CG2925;
Organism Drosophila melanogaster(Fruit fly)
NCBI Taxa ID 7227
Functional Description
(View all)
Probable subunit of a splicing factor complex required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (By similarity). Involved in male fertility.
Phosphorylation Sites
dbPAF PTMs: 3
PositionPeptidesSourceReferences ( PMIDs )
360TGGERDDSDVEASESdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
365DDSDVEASESDNEDDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
367SDVEASESDNEDDPDdbPTM 3.0;Phospho.ELM 9.0;PHOSIDA;PhosphoPep 2.0;SysPTM 2.0;UniProt;curated18327897; 16381945; 23193290; 21081558; 19060867; 19366988;
Sequence
(Fasta)
METLLEQQRR LHEERERLVK LMVDEHATKK PGEKERIHSE HRLKYLMELH HNSTSQLRDL 60
YEDKDNERKA EIAALSGPNE FNEFYARLKQ IKQFYKSHPA EVSVPLSVEF DEMIRVYNNP 120
DDMSALVEFT DEEGGGRYLD LNECYELYLN LRSVEKLDYI TYLMSFDHVF DIPRERKNRE 180
YRIYIETLND YLHHFILRIQ PLLDLEGELL KVELDFQRQW LMGTFPGFSI KETESALANT 240
GAHLDLSAFS SWEELASLGL DRLKSALVAL GLKCGGTLEE RAQRLFSTKG KSTLDPALMA 300
KKPSAKTASA QSREHERHKE IAQLEALLYK YADLLSEQRA ATKENVQRKQ ARTGGERDDS 360
DVEASESDNE DDPDADDVPY NPKNLPLGWD GKPIPYWLYK LHGLNISYNC EICGNFTYKG 420
PKAFQRHFAE WRHAHGMRCL GIPNTAHFAN VTQIEDAITL WEKLKSQKQS ERWVADQEEE 480
FEDSLGNVVN RKTFEDLKRQ GLL 504
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0747--Spliceosome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR024598--DUF3449
IPR031776--SF3A3
IPR031774--SF3A3_dom
IPR021966--SF3a60_bindingd
IPR015880--Znf_C2H2-like
IPR000690--Znf_C2H2_matrin

PROSITE

PS50171--ZF_MATRIN

Pfam

PF11931--DUF3449
PF16837--SF3A3
PF12108--SF3a60_bindingd

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0071011--C:precatalytic spliceosome
GO:0005686--C:U2 snRNP
GO:0044822--F:poly(A) RNA binding
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0009566--P:fertilization
GO:0007067--P:mitotic nuclear division
GO:0007052--P:mitotic spindle organization
GO:0000398--P:mRNA splicing, via spliceosome
GO:0051533--P:positive regulation of NFAT protein import into nucleus
GO:0051726--P:regulation of cell cycle