| Tag |
Content |
| dbPAF ID |
dbPAF-0001804 |
| Uniprot Accession |
O46043; PARG_DROME; M9NEU9; Q960N8;
|
| Genbank Protein ID |
NP_001245511.1; NP_477321.2;
|
| Genbank Nucleotide ID |
NM_001258582.2; NM_057973.4;
|
| Protein Name |
Poly(ADP-ribose) glycohydrolase |
| Protein Synonyms/Alias |
|
| Gene Name |
Parg |
| Gene Synonyms/Alias |
CG2864; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells.Functional Description
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism is required for maintenance of the normal function of neuronal cells. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MSKSPDGGIS EIETEEEPEN LANSLDDSWR GVSMEAIHRN RQPFELENLP PVTAGNLHRV 60
MYQLPIRETP PRPYKSPGKW DSEHVRLPCA PESKYPRENP DGSTTIDFRW EMIERALLQP 120
IKTCEELQAA IISYNTTYRD QWHFRALHQL LDEELDESET RVFFEDLLPR IIRLALRLPD 180
LIQSPVPLLK HHKNASLSLS QQQISCLLAN AFLCTFPRRN TLKRKSEYST FPDINFNRLY 240
QSTGPAVLEK LKCIMHYFRR VCPTERDASN VPTGVVTFVR RSGLPEHLID WSQSAAPLGD 300
VPLHVDAEGT IEDEGIGLLQ VDFANKYLGG GVLGHGCVQE EIRFVICPEL LVGKLFTECL 360
RPFEALVMLG AERYSNYTGY AGSFEWSGNF EDSTPRDSSG RRQTAIVAID ALHFAQSHHQ 420
YREDLMEREL NKAYIGFVHW MVTPPPGVAT GNWGCGAFGG DSYLKALLQL MVCAQLGRPL 480
AYYTFGNVEF RDDFHEMWLL FRNDGTTVQQ LWSILRSYSR LIKEKSSKEP RENKASKKKL 540
YDFIKEELKK VRDVPGEGAS AEAGSSRVAG LGEGKSETSA KSSPELNKQP ARPQITITQQ 600
STDLLPAQLS QDNSNSSEDQ ALLMLSDDEE ANAMMEAASL EAKSSVEISN SSTTSKTSST 660
ATKSMGSGGR QLSLLEMLDT HYEKGSASKR PRKSPNCSKA EGSAKSRKEI DVTDKDEKDD 720
IVD
724Fasta Sequence
>O46043|Parg|Drosophila melanogaster(Fruit fly)
MSKSPDGGISEIETEEEPENLANSLDDSWRGVSMEAIHRNRQPFELENLPPVTAGNLHRVMYQLPIRETPPRPYKSPGKWDSEHVRLPCAPESKYPRENPDGSTTIDFRWEMIERALLQPIKTCEELQAAIISYNTTYRDQWHFRALHQLLDEELDESETRVFFEDLLPRIIRLALRLPDLIQSPVPLLKHHKNASLSLSQQQISCLLANAFLCTFPRRNTLKRKSEYSTFPDINFNRLYQSTGPAVLEKLKCIMHYFRRVCPTERDASNVPTGVVTFVRRSGLPEHLIDWSQSAAPLGDVPLHVDAEGTIEDEGIGLLQVDFANKYLGGGVLGHGCVQEEIRFVICPELLVGKLFTECLRPFEALVMLGAERYSNYTGYAGSFEWSGNFEDSTPRDSSGRRQTAIVAIDALHFAQSHHQYREDLMERELNKAYIGFVHWMVTPPPGVATGNWGCGAFGGDSYLKALLQLMVCAQLGRPLAYYTFGNVEFRDDFHEMWLLFRNDGTTVQQLWSILRSYSRLIKEKSSKEPRENKASKKKLYDFIKEELKKVRDVPGEGASAEAGSSRVAGLGEGKSETSAKSSPELNKQPARPQITITQQSTDLLPAQLSQDNSNSSEDQALLMLSDDEEANAMMEAASLEAKSSVEISNSSTTSKTSSTATKSMGSGGRQLSLLEMLDTHYEKGSASKRPRKSPNCSKAEGSAKSRKEIDVTDKDEKDDIVD
|
| Keyword |
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
|
| Interpro |
IPR007724--Poly_GlycHdrlase
|
| PROSITE |
|
| Pfam |
PF05028--PARG_cat
|
| Gene Ontology |
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004649--F:poly(ADP-ribose) glycohydrolase activity
GO:0030576--P:Cajal body organization
GO:0005975--P:carbohydrate metabolic process
GO:0006342--P:chromatin silencing
GO:0036099--P:female germ-line stem cell population maintenance
GO:0051457--P:maintenance of protein location in nucleus
GO:0006909--P:phagocytosis
GO:0035065--P:regulation of histone acetylation
GO:0043484--P:regulation of RNA splicing
GO:0009408--P:response to heat
|
