| Tag |
Content |
| dbPAF ID |
dbPAF-0001802 |
| Uniprot Accession |
O46036; CTBP_DROME; O61283; Q59DX5; Q95SQ8; Q9VG02;
|
| Genbank Protein ID |
NP_001014617.1; NP_001262520.1; NP_524336.2; NP_731762.1; NP_731763.1; NP_731764.1;
|
| Genbank Nucleotide ID |
NM_001014617.2; NM_001275591.1; NM_079612.3; NM_169490.2; NM_169491.2; NM_169492.2;
|
| Protein Name |
C-terminal-binding protein |
| Protein Synonyms/Alias |
|
| Gene Name |
CtBP |
| Gene Synonyms/Alias |
CG7583; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression.Functional Description
Corepressor targeting diverse transcription regulators. Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 359 | NKEYFMRTPPAAAAG | PhosphoPep 2.0;curated | 19060867; 22817900 |
|
Sequence
(Fasta) | MDKNLMMPKR SRIDVKGNFA NGPLQARPLV ALLDGRDCSI EMPILKDVAT VAFCDAQSTS 60
EIHEKVLNEA VGALMWHTII LTKEDLEKFK ALRIIVRIGS GTDNIDVKAA GELGIAVCNV 120
PGYGVEEVAD TTMCLILNLY RRTYWLANMV REGKKFTGPE QVREAAHGCA RIRGDTLGLV 180
GLGRIGSAVA LRAKAFGFNV IFYDPYLPDG IDKSLGLTRV YTLQDLLFQS DCVSLHCTLN 240
EHNHHLINEF TIKQMRPGAF LVNTARGGLV DDETLALALK QGRIRAAALD VHENEPYNVF 300
QGALKDAPNL ICTPHAAFFS DASATELREM AATEIRRAIV GNIPDVLRNC VNKEYFMRTP 360
PAAAAGGVAA AVYPEGALHH RAHSTTPHDG PHSTTNLGST VGGGPTTVAQ AAAAAVAAAA 420
AAALLPSPVP SHLSPQVGGL PLGIVSSQSP LSAPDPNNHL SSSIKTEVKA ESTEAP
477Fasta Sequence
>O46036|CtBP|Drosophila melanogaster(Fruit fly)
MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGALHHRAHSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVPSHLSPQVGGLPLGIVSSQSPLSAPDPNNHLSSSIKTEVKAESTEAP
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
|
| Interpro |
IPR006139--D-isomer_2_OHA_DH_cat_dom
IPR029753--D-isomer_DH_CS
IPR006140--D-isomer_DH_NAD-bd
IPR016040--NAD(P)-bd_dom
|
| PROSITE |
PS00671--D_2_HYDROXYACID_DH_3
|
| Pfam |
PF00389--2-Hacid_dh
PF02826--2-Hacid_dh_C
|
| Gene Ontology |
GO:0031010--C:ISWI-type complex
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0051287--F:NAD binding
GO:0016616--F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803--F:protein homodimerization activity
GO:0070491--F:repressing transcription factor binding
GO:0003713--F:transcription coactivator activity
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0022416--P:chaeta development
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0046427--P:positive regulation of JAK-STAT cascade
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0030111--P:regulation of Wnt signaling pathway
GO:0016360--P:sensory organ precursor cell fate determination
GO:0006351--P:transcription, DNA-templated
GO:0035220--P:wing disc development
GO:0016055--P:Wnt signaling pathway
|
