| Tag |
Content |
| dbPAF ID |
dbPAF-0001722 |
| Uniprot Accession |
O44783; SPY_DROME; A4V1F3; Q6AWR4; Q9VZP7;
|
| Genbank Protein ID |
NP_523902.2; NP_728881.1;
|
| Genbank Nucleotide ID |
NM_079178.3; NM_168031.2;
|
| Protein Name |
Protein sprouty |
| Protein Synonyms/Alias |
|
| Gene Name |
sty |
| Gene Synonyms/Alias |
CG1921; |
| Organism |
Drosophila melanogaster(Fruit fly) |
| NCBI Taxa ID |
7227 |
Functional Description
(View all) |
Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells.Functional Description
Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells. |
Phosphorylation Sites
|
dbPAF PTMs: 6 |
Sequence
(Fasta) | MDRRNGGDPL APPRPPKLLP RVHRPRAPEP TLSGVDHNAG ATASALASGA SSAAPVAIHN 60
NNSQQQLSIS AAASNNNTIS IIPASPDFDD YQIHHLTFLP QRPSSLSRNS STASSTTATG 120
ISVSGSGSVS GSSSSFTRRR PPAPVPLNNS ISNNNNNSIN NNFLSHFQSA EPASNALGQP 180
PASPVTLAQP RPESERLTNE YVDTPLQHAT RSQHPAGQQD NGQTTTHHLL LLPQRNQHLH 240
LQQHQQHLQQ QQQQQQQQQQ QQHLQHQQNQ QHARLATTTQ ATSVGSDHTD GLLHSHLQNS 300
TTKPPASKQP APPRLGMGLG LGLGLGLNQP IITKQPTPAT QKERMHALEE LLQPGGAGGN 360
GGPLVMAGDP SLLNPIVCPR CGRCRCEQCQ SPRPLPQTWV CNKTCLCSAE SVIDYASCLC 420
CAKALFYHCA RDNDLDCDDG NGTPCVDNPC SCGPYKRTQR WGWLGALSIF LPCLWFYWPM 480
RGCMKLCEKC YGRFAGRGCR CQGIGGGGAG SGGGVGSIGS TSSMLPIVPL GVNGSGLGGG 540
VSLSGGVTDG GLNQANGKAM DHGCSAARSI LRKGDLTPEK RLLDSSPDY
Fasta Sequence
>O44783|sty|Drosophila melanogaster(Fruit fly)
MDRRNGGDPLAPPRPPKLLPRVHRPRAPEPTLSGVDHNAGATASALASGASSAAPVAIHNNNSQQQLSISAAASNNNTISIIPASPDFDDYQIHHLTFLPQRPSSLSRNSSTASSTTATGISVSGSGSVSGSSSSFTRRRPPAPVPLNNSISNNNNNSINNNFLSHFQSAEPASNALGQPPASPVTLAQPRPESERLTNEYVDTPLQHATRSQHPAGQQDNGQTTTHHLLLLPQRNQHLHLQQHQQHLQQQQQQQQQQQQQQHLQHQQNQQHARLATTTQATSVGSDHTDGLLHSHLQNSTTKPPASKQPAPPRLGMGLGLGLGLGLNQPIITKQPTPATQKERMHALEELLQPGGAGGNGGPLVMAGDPSLLNPIVCPRCGRCRCEQCQSPRPLPQTWVCNKTCLCSAESVIDYASCLCCAKALFYHCARDNDLDCDDGNGTPCVDNPCSCGPYKRTQRWGWLGALSIFLPCLWFYWPMRGCMKLCEKCYGRFAGRGCRCQGIGGGGAGSGGGVGSIGSTSSMLPIVPLGVNGSGLGGGVSLSGGVTDGGLNQANGKAMDHGCSAARSILRKGDLTPEKRLLDSSPDY
|
| Keyword |
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0472--Membrane
KW-1185--Reference proteome
|
| Interpro |
IPR007875--Sprouty
|
| PROSITE |
PS51227--SPR
|
| Pfam |
PF05210--Sprouty
|
| Gene Ontology |
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0060446--P:branching involved in open tracheal system development
GO:0001745--P:compound eye morphogenesis
GO:0021782--P:glial cell development
GO:0001763--P:morphogenesis of a branching structure
GO:0048747--P:muscle fiber development
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0040037--P:negative regulation of fibroblast growth factor receptor signaling pathway
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0009968--P:negative regulation of signal transduction
GO:0035155--P:negative regulation of terminal cell fate specification, open tracheal system
GO:0016318--P:ommatidial rotation
GO:0007424--P:open tracheal system development
GO:0030707--P:ovarian follicle cell development
GO:0045314--P:regulation of compound eye photoreceptor development
GO:0007429--P:secondary branching, open tracheal system
GO:0007430--P:terminal branching, open tracheal system
GO:0008293--P:torso signaling pathway
GO:0007426--P:tracheal outgrowth, open tracheal system
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
|
