dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001685
Uniprot Accession O43933; PEX1_HUMAN; A4D1G3; A8KA90; B4DIM7; E9PE75; Q96S71; Q96S72; Q96S73; Q99994;
Genbank Protein ID NP_000457.1; NP_001269606.1; NP_001269607.1;
Genbank Nucleotide ID NM_000466.2; NM_001282677.1; NM_001282678.1;
Protein Name Peroxisome biogenesis factor 1
Protein Synonyms/Alias Peroxin-1;Peroxisome biogenesis disorder protein 1;
Gene Name PEX1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.
Phosphorylation Sites
 dbPAF PTMs: 19
PositionPeptidesSourceReferences ( PMIDs )
202EYKKLHSYGRDQKGMPhosphoSitePlus22135298
264SEKKQETSWGLTEINPhosphoSitePlus22135298
278NAFKNMQSKVVPLDNPhosphoSitePlus22135298
354KTKQNVLSPEKEKQMPhosphoSitePlus;curated22135298; 25627689; 22199227
438RITPVEVTPKIPRSLPhosphoSitePlus;curated22135298; 23186163
585PLSRQLMSLVAGLRNPhosphoSitePlus22135298
810TREKLVLTTLDFQKAPhosphoSitePlus22135298
811REKLVLTTLDFQKALPhosphoSitePlus22135298
880QRTGILLYGPPGTGKPhosphoSitePlus22135298
885LLYGPPGTGKTLLAGPhosphoSitePlus22135298
1172PGKDQLFSQPPVLRTPhosphoSitePlus;curated22135298; 25627689; 26074081
1179SQPPVLRTASQEGCQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18669648; 16381945; 23193290; 20166139; 18988627; 19060867;
1181PPVLRTASQEGCQELdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated17525332; 19413330; 16381945; 23193290; 18669648; 20562096;
1201DQLRADISIIKGRYRPhosphoSitePlus22135298
1207ISIIKGRYRSQSGEDPhosphoSitePlus22135298
1209IIKGRYRSQSGEDESdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 19664995; 20068231; 21406692;
1211KGRYRSQSGEDESMNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated19413330; 16381945; 23193290; 18669648; 19664994; 19664995;
1216SQSGEDESMNQPGPIPhosphoSitePlus;curated22135298; 25627689; 23186163
1270PKRRKNQSGTMFRPGPhosphoSitePlus;curated22135298; 25627689; 23186163
Sequence
(Fasta)		MWGSDRLAGA GGGGAAVTVA FTNARDCFLH LPRRLVAQLH LLQNQAIEVV WSHQPAFLSW 60
VEGRHFSDQG ENVAEINRQV GQKLGLSNGG QVFLKPCSHV VSCQQVEVEP LSADDWEILE 120
LHAVSLEQHL LDQIRIVFPK AIFPVWVDQQ TYIFIQIVAL IPAASYGRLE TDTKLLIQPK 180
TRRAKENTFS KADAEYKKLH SYGRDQKGMM KELQTKQLQS NTVGITESNE NESEIPVDSS 240
SVASLWTMIG SIFSFQSEKK QETSWGLTEI NAFKNMQSKV VPLDNIFRVC KSQPPSIYNA 300
SATSVFHKHC AIHVFPWDQE YFDVEPSFTV TYGKLVKLLS PKQQQSKTKQ NVLSPEKEKQ 360
MSEPLDQKKI RSDHNEEDEK ACVLQVVWNG LEELNNAIKY TKNVEVLHLG KVWIPDDLRK 420
RLNIEMHAVV RITPVEVTPK IPRSLKLQPR ENLPKDISEE DIKTVFYSWL QQSTTTMLPL 480
VISEEEFIKL ETKDGLKEFS LSIVHSWEKE KDKNIFLLSP NLLQKTTIQV LLDPMVKEEN 540
SEEIDFILPF LKLSSLGGVN SLGVSSLEHI THSLLGRPLS RQLMSLVAGL RNGALLLTGG 600
KGSGKSTLAK AICKEAFDKL DAHVERVDCK ALRGKRLENI QKTLEVAFSE AVWMQPSVVL 660
LDDLDLIAGL PAVPEHEHSP DAVQSQRLAH ALNDMIKEFI SMGSLVALIA TSQSQQSLHP 720
LLVSAQGVHI FQCVQHIQPP NQEQRCEILC NVIKNKLDCD INKFTDLDLQ HVAKETGGFV 780
ARDFTVLVDR AIHSRLSRQS ISTREKLVLT TLDFQKALRG FLPASLRSVN LHKPRDLGWD 840
KIGGLHEVRQ ILMDTIQLPA KYPELFANLP IRQRTGILLY GPPGTGKTLL AGVIARESRM 900
NFISVKGPEL LSKYIGASEQ AVRDIFIRAQ AAKPCILFFD EFESIAPRRG HDNTGVTDRV 960
VNQLLTQLDG VEGLQGVYVL AATSRPDLID PALLRPGRLD KCVYCPPPDQ VSRLEILNVL 1020
SDSLPLADDV DLQHVASVTD SFTGADLKAL LYNAQLEALH GMLLSSGLQD GSSSSDSDLS 1080
LSSMVFLNHS SGSDDSAGDG ECGLDQSLVS LEMSEILPDE SKFNMYRLYF GSSYESELGN 1140
GTSSDLSSQC LSAPSSMTQD LPGVPGKDQL FSQPPVLRTA SQEGCQELTQ EQRDQLRADI 1200
SIIKGRYRSQ SGEDESMNQP GPIKTRLAIS QSHLMTALGH TRPSISEDDW KNFAELYESF 1260
QNPKRRKNQS GTMFRPGQKV TLA 1284
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-0958--Peroxisome biogenesis disorder
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0861--Zellweger syndrome
Interpro

IPR003593--AAA+_ATPase
IPR009010--Asp_de-COase-like_dom
IPR003959--ATPase_AAA_core
IPR003960--ATPase_AAA_CS
IPR029067--CDC48_domain_2-like
IPR027417--P-loop_NTPase
IPR015343--PEX-N_a/b
IPR015342--PEX-N_psi_beta-barrel
IPR025653--Pex1
PROSITE

PS00674--AAA
Pfam

PF00004--AAA
PF09262--PEX-1N
PF09263--PEX-2N
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005778--C:peroxisomal membrane
GO:0005777--C:peroxisome
GO:0005524--F:ATP binding
GO:0042623--F:ATPase activity, coupled
GO:0008022--F:protein C-terminus binding
GO:0032403--F:protein complex binding
GO:0060152--P:microtubule-based peroxisome localization
GO:0007031--P:peroxisome organization
GO:0016558--P:protein import into peroxisome matrix
GO:0006625--P:protein targeting to peroxisome