dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001683
Uniprot Accession O43929; ORC4_HUMAN; B7Z3D0; B7Z5F1; D3DP86; F5H069; Q96C42;
Genbank Protein ID NP_001177808.1; NP_001177810.1; NP_001177811.1; NP_002543.2; NP_859525.1; NP_859526.1; XP_006712619.1; XP_011509557.1;
Genbank Nucleotide ID NM_001190879.2; NM_001190881.2; NM_001190882.2; NM_002552.4; NM_181741.3; NM_181742.3; XM_006712556.2; XM_011511255.1;
Protein Name Origin recognition complex subunit 4
Protein Synonyms/Alias
Gene Name ORC4
Gene Synonyms/Alias ORC4L;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Phosphorylation Sites
 dbPAF PTMs: 8
PositionPeptidesSourceReferences ( PMIDs )
6--MSSRKSKSNSLIHPhosphoSitePlus22135298
8MSSRKSKSNSLIHTEdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
10SRKSKSNSLIHTECLPhosphoSitePlus22135298
35FCRQSPHSNLFGVQVdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
48QVQYKHLSELLKRTAPhosphoSitePlus22135298
54LSELLKRTALHGESNPhosphoSitePlus22135298
235KIFKEQLSLPAEFPDPhosphoSitePlus22135298
278NISKNLRSLHMLLMLPHOSIDA21081558
Sequence
(Fasta)		MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL LKRTALHGES 60
NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL 120
ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS 180
QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF 240
PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV 300
DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK 360
AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN 420
CPTDVRQWAT SSLSWL 437
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0235--DNA replication
KW-0238--DNA-binding
KW-0242--Dwarfism
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR003593--AAA+_ATPase
IPR016527--ORC4
IPR027417--P-loop_NTPase
PROSITE
Pfam
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005737--C:cytoplasm
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000808--C:origin recognition complex
GO:0005524--F:ATP binding
GO:0003688--F:DNA replication origin binding
GO:0000166--F:nucleotide binding
GO:0006260--P:DNA replication
GO:0006270--P:DNA replication initiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle