| Tag |
Content |
| dbPAF ID |
dbPAF-0001682 |
| Uniprot Accession |
O43927; CXL13_HUMAN;
|
| Genbank Protein ID |
NP_006410.1; XP_006714126.1;
|
| Genbank Nucleotide ID |
NM_006419.2; XM_006714063.2;
|
| Protein Name |
C-X-C motif chemokine 13 |
| Protein Synonyms/Alias |
Angie;B cell-attracting chemokine 1;BCA-1;B lymphocyte chemoattractant;CXC chemokine BLC;Small-inducible cytokine B13; |
| Gene Name |
CXCL13 |
| Gene Synonyms/Alias |
BCA1;BLC;SCYB13; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5.Functional Description
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR IQILPRGNGC 60
PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP VPVFKRKIP
Fasta Sequence
>O43927|CXCL13|Homo sapiens(Human)
MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP
|
| Keyword |
KW-0002--3D-structure
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-0202--Cytokine
KW-1015--Disulfide bond
KW-0395--Inflammatory response
KW-1185--Reference proteome
KW-0964--Secreted
KW-0732--Signal
|
| Interpro |
IPR001089--Chemokine_CXC
IPR018048--Chemokine_CXC_CS
IPR001811--Chemokine_IL8-like_dom
|
| PROSITE |
PS00471--SMALL_CYTOKINES_CXC
|
| Pfam |
PF00048--IL8
|
| Gene Ontology |
GO:0005829--C:cytosol
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:0031735--F:CCR10 chemokine receptor binding
GO:0008009--F:chemokine activity
GO:0048248--F:CXCR3 chemokine receptor binding
GO:0031724--F:CXCR5 chemokine receptor binding
GO:0017134--F:fibroblast growth factor binding
GO:0008201--F:heparin binding
GO:0046982--F:protein heterodimerization activity
GO:0048018--F:receptor agonist activity
GO:0090630--P:activation of GTPase activity
GO:0035754--P:B cell chemotaxis
GO:0035769--P:B cell chemotaxis across high endothelial venule
GO:0007166--P:cell surface receptor signaling pathway
GO:0007267--P:cell-cell signaling
GO:0070098--P:chemokine-mediated signaling pathway
GO:0002544--P:chronic inflammatory response
GO:0042742--P:defense response to bacterium
GO:0035768--P:endothelial cell chemotaxis to fibroblast growth factor
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0002467--P:germinal center formation
GO:0006955--P:immune response
GO:0006954--P:inflammatory response
GO:0048535--P:lymph node development
GO:0002518--P:lymphocyte chemotaxis across high endothelial venule
GO:2000545--P:negative regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:0033634--P:positive regulation of cell-cell adhesion mediated by integrin
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0033625--P:positive regulation of integrin activation
GO:0010820--P:positive regulation of T cell chemotaxis
GO:0045765--P:regulation of angiogenesis
GO:0042127--P:regulation of cell proliferation
GO:0002920--P:regulation of humoral immune response
GO:0032496--P:response to lipopolysaccharide
|
