dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001679
Uniprot Accession O43914; TYOBP_HUMAN; A8K2X0; F5H389; Q6FGA5; Q9UMT3;
Genbank Protein ID NP_001166985.1; NP_003323.1; NP_937758.1;
Genbank Nucleotide ID NM_001173514.1; NM_003332.3; NM_198125.2;
Protein Name TYRO protein tyrosine kinase-binding protein
Protein Synonyms/Alias DNAX-activation protein 12;Killer-activating receptor-associated protein;KAR-associated protein;
Gene Name TYROBP
Gene Synonyms/Alias DAP12;KARAP;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
Phosphorylation Sites
 dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
89QRITETESPYQELQGPhosphoPep 2.0;PhosphoSitePlus19060867; 22135298
91ITETESPYQELQGQRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 19369195; 16381945; 23193290; 9490415; 17360941; 1
102QGQRSDVYSDLNTQRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated9490415; 16381945; 23193290; 18988627; 22135298; 22817900
111DLNTQRPYYK-----PhosphoSitePlus22135298
112LNTQRPYYK------PhosphoSitePlus22135298
Sequence
(Fasta)		MGGLEPCSRL LLLPLLLAVS GLRPVQAQAQ SDCSCSTVSP GVLAGIVMGD LVLTVLIALA 60
VYFLGRLVPR GRGAAEAATR KQRITETESP YQELQGQRSD VYSDLNTQRP YYK 114
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR026200--Tyrobp
PROSITE
Pfam
Gene Ontology

GO:0009986--C:cell surface
GO:0005887--C:integral component of plasma membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0042802--F:identical protein binding
GO:0005102--F:receptor binding
GO:0005057--F:receptor signaling protein activity
GO:0007411--P:axon guidance
GO:0006968--P:cellular defense response
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0002281--P:macrophage activation involved in immune response
GO:0002283--P:neutrophil activation involved in immune response
GO:0050776--P:regulation of immune response
GO:2001204--P:regulation of osteoclast development
GO:0007165--P:signal transduction