dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001678
Uniprot Accession O43913; ORC5_HUMAN; A4D0P8; O60590; O95268;
Genbank Protein ID NP_002544.1; NP_859531.1;
Genbank Nucleotide ID NM_002553.3; NM_181747.3;
Protein Name Origin recognition complex subunit 5
Protein Synonyms/Alias
Gene Name ORC5
Gene Synonyms/Alias ORC5L;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
86KLNHLSSSEDGCSTEPhosphoSitePlus22135298
236AVLNFPKYCEPVVKGPhosphoSitePlus22135298
Sequence
(Fasta)		MPHLENVVLC RESQVSILQS LFGERHHFSF PSIFIYGHTA SGKTYVTQTL LKTLELPHVF 60
VNCVECFTLR LLLEQILNKL NHLSSSEDGC STEITCETFN DFVRLFKQVT TAENLKDQTV 120
YIVLDKAEYL RDMEANLLPG FLRLQELADR NVTVLFLSEI VWEKFRPNTG CFEPFVLYFP 180
DYSIGNLQKI LSHDHPPEYS ADFYAAYINI LLGVFYTVCR DLKELRHLAV LNFPKYCEPV 240
VKGEASERDT RKLWRNIEPH LKKAMQTVYL REISSSQWEK LQKDDTDPGQ LKGLSAHTHV 300
ELPYYSKFIL IAAYLASYNP ARTDKRFFLK HHGKIKKTNF LKKHEKTSNH LLGPKPFPLD 360
RLLAILYSIV DSRVAPTANI FSQITSLVTL QLLTLVGHDD QLDGPKYKCT VSLDFIRAIA 420
RTVNFDIIKY LYDFL 436
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0235--DNA replication
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR020796--ORC5
IPR027417--P-loop_NTPase
PROSITE
Pfam

PF14630--ORC5_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005664--C:nuclear origin of replication recognition complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000808--C:origin recognition complex
GO:0005524--F:ATP binding
GO:0003688--F:DNA replication origin binding
GO:0000166--F:nucleotide binding
GO:0006260--P:DNA replication
GO:0006270--P:DNA replication initiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle