dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001675
Uniprot Accession O43903; GAS2_HUMAN; B2R9C8; D3DQZ0; Q6ICV8; Q7Z3X8;
Genbank Protein ID NP_001137302.1; NP_005247.1; NP_808221.1;
Genbank Nucleotide ID NM_001143830.1; NM_005256.3; NM_177553.2;
Protein Name Growth arrest-specific protein 2
Protein Synonyms/Alias
Gene Name GAS2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 14
PositionPeptidesSourceReferences ( PMIDs )
100LKKIPCKTSAPSGSFPhosphoSitePlus22135298
101KKIPCKTSAPSGSFFPhosphoSitePlus22135298
104PCKTSAPSGSFFARDPhosphoSitePlus22135298
106KTSAPSGSFFARDNTPhosphoSitePlus22135298
183EETLSAPSPSPSPSSPhosphoSitePlus22135298
185TLSAPSPSPSPSSKSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 22817900
187SAPSPSPSPSSKSSGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;UniProt;curated18669648; 16381945; 23193290; 18988627; 22135298; 24275569;
190SPSPSPSSKSSGKKSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 22817900
197SKSSGKKSTGNLLDDcurated22798277
258RVGGGWETFAGYLLKPhosphoSitePlus22135298
262GWETFAGYLLKHDPCPhosphoSitePlus22135298
281ISRVDGKTSPIQSKScurated22798277
282SRVDGKTSPIQSKSPPhosphoSitePlus22135298
288TSPIQSKSPTLKDMNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20166139; 16381945; 23193290; 18988627; 22135298; 22817900
Sequence
(Fasta)		MCTALSPKVR SGPGLSDMHQ YSQWLASRHE ANLLPMKEDL ALWLTNLLGK EITAETFMEK 60
LDNGALLCQL AETMQEKFKE SMDANKPTKN LPLKKIPCKT SAPSGSFFAR DNTANFLSWC 120
RDLGVDETCL FESEGLVLHK QPREVCLCLL ELGRIAARYG VEPPGLIKLE KEIEQEETLS 180
APSPSPSPSS KSSGKKSTGN LLDDAVKRIS EDPPCKCPNK FCVERLSQGR YRVGEKILFI 240
RMLHNKHVMV RVGGGWETFA GYLLKHDPCR MLQISRVDGK TSPIQSKSPT LKDMNPDNYL 300
VVSASYKAKK EIK 314
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0133--Cell shape
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0338--Growth arrest
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR001715--CH-domain
IPR029929--GAS2
IPR003108--GAS2_dom
PROSITE

PS50021--CH
PS51460--GAR
Pfam

PF00307--CH
PF02187--GAS2
Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006921--P:cellular component disassembly involved in execution phase of apoptosis
GO:0012501--P:programmed cell death
GO:0008360--P:regulation of cell shape