dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001672
Uniprot Accession O43896; KIF1C_HUMAN; D3DTL6; O75186; Q5U618;
Genbank Protein ID NP_006603.2; XP_005256481.1;
Genbank Nucleotide ID NM_006612.5; XM_005256424.1;
Protein Name Kinesin-like protein KIF1C
Protein Synonyms/Alias
Gene Name KIF1C
Gene Synonyms/Alias KIAA0706;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
Phosphorylation Sites
 dbPAF PTMs: 35 (View all)
PositionPeptidesSourceReferences ( PMIDs )
222SRSHAVFTIVFTQRCPhosphoSitePlus22135298
257AGSERADSSGARGMRPhosphoSitePlus22135298
258GSERADSSGARGMRLPhosphoSitePlus22135298
274EGANINKSLTTLGKVPhosphoSitePlus22135298
276ANINKSLTTLGKVISPhosphoSitePlus22135298
277NINKSLTTLGKVISAPhosphoSitePlus22135298
295MQSKKRKSDFIPYRDPhosphoSitePlus;curated22135298; 23186163; 21857030
326TAMIAALSPADINYEPhosphoSitePlus22135298
332LSPADINYEETLSTLPhosphoSitePlus22135298
412SSPPAPVSPSSPTTHPhosphoSitePlus;curated22135298; 26074081
489AVREDGGTVGVFSPKdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
494GGTVGVFSPKKTPHLdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 19690332; 16381945; 23193290; 20068231; 22067460;
654LQDLENQYRKEKEEAcurated26074081
671LLEQQRLYADSDSGDdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
674QQRLYADSDSGDDSDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;UniProt;curated17081983; 16381945; 23193290; 20068231; 20164059; 20363803;
676RLYADSDSGDDSDKRdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated20068231; 20164059; 20363803; 21406692; 21659604; 16381945;
680DSDSGDDSDKRSCEEdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated19651622; 16381945; 23193290; 18988627; 22135298; 17081983;
694ESWRLISSLREQLPPSysPTM 2.017322306; 19366988
702LREQLPPTTVQTIVKdbPTM 3.0;PhosphoSitePlus;curated20164059; 16381945; 23193290; 22135298; 22817900
703REQLPPTTVQTIVKRdbPTM 3.0;PhosphoSitePlus;curated20164059; 16381945; 23193290; 22135298; 22817900
Sequence
(Fasta)		MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSKDAPKSF TFDYSYWSHT 60
STEDPQFASQ QQVYRDIGEE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGR QEPGQQGIVP 120
QLCEDLFSRV SENQSAQLSY SVEVSYMEIY CERVRDLLNP KSRGSLRVRE HPILGPYVQD 180
LSKLAVTSYA DIADLMDCGN KARTVAATNM NETSSRSHAV FTIVFTQRCH DQLTGLDSEK 240
VSKISLVDLA GSERADSSGA RGMRLKEGAN INKSLTTLGK VISALADMQS KKRKSDFIPY 300
RDSVLTWLLK ENLGGNSRTA MIAALSPADI NYEETLSTLR YADRTKQIRC NAIINEDPNA 360
RLIRELQEEV ARLRELLMAQ GLSASALEGL KTEEGSVRGA LPAVSSPPAP VSPSSPTTHN 420
GELEPSFSPN TESQIGPEEA MERLQETEKI IAELNETWEE KLRKTEALRM EREALLAEMG 480
VAVREDGGTV GVFSPKKTPH LVNLNEDPLM SECLLYHIKD GVTRVGQVDM DIKLTGQFIR 540
EQHCLFRSIP QPDGEVVVTL EPCEGAETYV NGKLVTEPLV LKSGNRIVMG KNHVFRFNHP 600
EQARLERERG VPPPPGPPSE PVDWNFAQKE LLEQQGIDIK LEMEKRLQDL ENQYRKEKEE 660
ADLLLEQQRL YADSDSGDDS DKRSCEESWR LISSLREQLP PTTVQTIVKR CGLPSSGKRR 720
APRRVYQIPQ RRRLQGKDPR WATMADLKMQ AVKEICYEVA LADFRHGRAE IEALAALKMR 780
ELCRTYGKPD GPGDAWRAVA RDVWDTVGEE EGGGAGSGGG SEEGARGAEV EDLRAHIDKL 840
TGILQEVKLQ NSSKDRELQA LRDRMLRMER VIPLAQDHED ENEEGGEVPW APPEGSEAAE 900
EAAPSDRMPS ARPPSPPLSS WERVSRLMEE DPAFRRGRLR WLKQEQLRLQ GLQGSGGRGG 960
GLRRPPARFV PPHDCKLRFP FKSNPQHRES WPGMGSGEAP TPLQPPEEVT PHPATPARRP 1020
PSPRRSHHPR RNSLDGGGRS RGAGSAQPEP QHFQPKKHNS YPQPPQPYPA QRPPGPRYPP 1080
YTTPPRMRRQ RSAPDLKESG AAV 1104
Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0493--Microtubule
KW-0505--Motor protein
KW-0523--Neurodegeneration
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR000253--FHA_dom
IPR027640--Kinesin-like_fam
IPR032405--Kinesin_assoc
IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
IPR008984--SMAD_FHA_domain
PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
Pfam

PF00498--FHA
PF00225--Kinesin
PF16183--Kinesin_assoc
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0008574--F:ATP-dependent microtubule motor activity, plus-end-directed
GO:0003774--F:motor activity
GO:0044822--F:poly(A) RNA binding
GO:0030705--P:cytoskeleton-dependent intracellular transport
GO:0007018--P:microtubule-based movement
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER