dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001671
Uniprot Accession O43895; XPP2_HUMAN; A0AV16; O75994;
Genbank Protein ID NP_003390.4;
Genbank Nucleotide ID NM_003399.5;
Protein Name Xaa-Pro aminopeptidase 2
Protein Synonyms/Alias Aminoacylproline aminopeptidase;Membrane-bound aminopeptidase P;Membrane-bound APP;Membrane-bound AmP;mAmP;X-Pro aminopeptidase 2;
Gene Name XPNPEP2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin.
Phosphorylation Sites
 dbPAF PTMs: 9
PositionPeptidesSourceReferences ( PMIDs )
81TDAHMNEYIGQHDERPhosphoSitePlus22135298
221STWQEKVSGVRSQMQPhosphoSitePlus22135298
379DAVAVIRYLVWLEKNdbPTM 3.0;PhosphoSitePlus;curated19835603; 16381945; 23193290; 22135298; 22817900
422SFETISASGLNAALAPhosphoSitePlus22135298
431LNAALAHYSPTKELNPhosphoSitePlus22135298
432NAALAHYSPTKELNRPhosphoSitePlus22135298
442KELNRKLSSDEMYLLPhosphoSitePlus22135298
617HLQYLNRYYQTIREKdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20166139; 16381945; 23193290; 18988627; 22135298; 24260401
618LQYLNRYYQTIREKVdbPTM 3.0;HPRD 9;PhosphoSitePlus20166139; 16381945; 23193290; 18988627; 22135298
Sequence
(Fasta)		MARAHWGCCP WLVLLCACAW GHTKPVDLGG QDVRNCSTNP PYLPVTVVNT TMSLTALRQQ 60
MQTQNLSAYI IPGTDAHMNE YIGQHDERRA WITGFTGSAG TAVVTMKKAA VWTDSRYWTQ 120
AERQMDCNWE LHKEVGTTPI VTWLLTEIPA GGRVGFDPFL LSIDTWESYD LALQGSNRQL 180
VSITTNLVDL VWGSERPPVP NQPIYALQEA FTGSTWQEKV SGVRSQMQKH QKVPTAVLLS 240
ALEETAWLFN LRASDIPYNP FFYSYTLLTD SSIRLFANKS RFSSETLSYL NSSCTGPMCV 300
QIEDYSQVRD SIQAYSLGDV RIWIGTSYTM YGIYEMIPKE KLVTDTYSPV MMTKAVKNSK 360
EQALLKASHV RDAVAVIRYL VWLEKNVPKG TVDEFSGAEI VDKFRGEEQF SSGPSFETIS 420
ASGLNAALAH YSPTKELNRK LSSDEMYLLD SGGQYWDGTT DITRTVHWGT PSAFQKEAYT 480
RVLIGNIDLS RLIFPAATSG RMVEAFARRA LWDAGLNYGH GTGHGIGNFL CVHEWPVGFQ 540
SNNIAMAKGM FTSIEPGYYK DGEFGIRLED VALVVEAKTK YPGSYLTFEV VSFVPYDRNL 600
IDVSLLSPEH LQYLNRYYQT IREKVGPELQ RRQLLEEFEW LQQHTEPLAA RAPDTASWAS 660
VLVVSTLAIL GWSV 675
Keyword

KW-0031--Aminopeptidase
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0336--GPI-anchor
KW-0378--Hydrolase
KW-0449--Lipoprotein
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
Interpro

IPR029149--Creatin/AminoP/Spt16_NTD
IPR028980--Creatinase/Aminopeptidase_P_N
IPR000587--Creatinase_N
IPR000994--Pept_M24_structural-domain
IPR032416--Peptidase_M24_C
IPR001131--Peptidase_M24B_aminopep-P_CS
PROSITE

PS00491--PROLINE_PEPTIDASE
Pfam

PF01321--Creatinase_N
PF00557--Peptidase_M24
PF16188--Peptidase_M24_C
Gene Ontology

GO:0031225--C:anchored component of membrane
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0004177--F:aminopeptidase activity
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity