| Tag |
Content |
| dbPAF ID |
dbPAF-0001670 |
| Uniprot Accession |
O43889; CREB3_HUMAN; D0PTW6; O14671; O14919; Q5TCV1; Q96GK8; Q9H2W3; Q9UE77;
|
| Genbank Protein ID |
NP_006359.3;
|
| Genbank Nucleotide ID |
NM_006368.4;
|
| Protein Name |
Cyclic AMP-responsive element-binding protein 3 |
| Protein Synonyms/Alias |
|
| Gene Name |
CREB3 |
| Gene Synonyms/Alias |
LZIP; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.Functional Description
Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 46 | LPLSEVPSDWEVDDL | curated | 26074081 |
|
Sequence
(Fasta) | MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV DDLLCSLLSP 60
PASLNILSSS NPCLVHHDHT YSLPRETVSM DLGECEISLT GRTGFMGLAI HTFPFAESES 120
CRKEGTQMTP QHMEELAEQE IARLVLTDEE KSLLEKEGLI LPETLPLTKT EEQILKRVRR 180
KIRNKRSAQE SRRKKKVYVG GLESRVLKYT AQNMELQNKV QLLEEQNLSL LDQLRKLQAM 240
VIEISNKTSS SSTCILVLLV SFCLLLVPAM YSSDTRGSLP AEHGVLSRQL RALPSEDPYQ 300
LELPALQSEV PKDSTHQWLD GSDCVLQAPG NTSCLLHYMP QAPSAEPPLE WPFPDLFSEP 360
LCRGPILPLQ ANLTRKGGWL PTGSPSVILQ DRYSG
396Fasta Sequence
>O43889|CREB3|Homo sapiens(Human)
MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRETVSMDLGECEISLTGRTGFMGLAIHTFPFAESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISNKTSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQLELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG
|
| Keyword |
KW-0010--Activator
KW-0025--Alternative splicing
KW-0145--Chemotaxis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0735--Signal-anchor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0834--Unfolded protein response
|
| Interpro |
IPR004827--bZIP
IPR029808--Luman
|
| PROSITE |
PS50217--BZIP
PS00036--BZIP_BASIC
|
| Pfam |
PF00170--bZIP_1
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0035497--F:cAMP response element binding
GO:0008140--F:cAMP response element binding protein binding
GO:0031726--F:CCR1 chemokine receptor binding
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0046983--F:protein dimerization activity
GO:0042803--F:protein homodimerization activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000982--F:transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0006935--P:chemotaxis
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0019043--P:establishment of viral latency
GO:0050930--P:induction of positive chemotaxis
GO:0045786--P:negative regulation of cell cycle
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000326--P:negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
GO:0051928--P:positive regulation of calcium ion transport
GO:0030335--P:positive regulation of cell migration
GO:0090045--P:positive regulation of deacetylase activity
GO:0002230--P:positive regulation of defense response to virus by host
GO:0090026--P:positive regulation of monocyte chemotaxis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006990--P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0001558--P:regulation of cell growth
GO:0042127--P:regulation of cell proliferation
GO:0019046--P:release from viral latency
GO:0034976--P:response to endoplasmic reticulum stress
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0016032--P:viral process
|
