dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001668
Uniprot Accession O43868; S28A2_HUMAN; A8K7F9; O43239; Q52LZ0;
Genbank Protein ID NP_004203.2; XP_011520500.1;
Genbank Nucleotide ID NM_004212.3; XM_011522198.1;
Protein Name Sodium/nucleoside cotransporter 2
Protein Synonyms/Alias Concentrative nucleoside transporter 2;CNT 2;hCNT2;Na(+)/nucleoside cotransporter 2;Sodium-coupled nucleoside transporter 2;Sodium/purine nucleoside co-transporter;SPNT;Solute carrier family 28 member 2;
Gene Name SLC28A2
Gene Synonyms/Alias CNT2;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
55DGLGPSTYQRRSRWPPhosphoSitePlus22135298
377APCALASSKLAYPEVPhosphoSitePlus22135298
Sequence
(Fasta)		MEKASGRQSI ALSTVETGTV NPGLELMEKE VEPEGSKRTD AQGHSLGDGL GPSTYQRRSR 60
WPFSKARSFC KTHASLFKKI LLGLLCLAYA AYLLAACILN FQRALALFVI TCLVIFVLVH 120
SFLKKLLGKK LTRCLKPFEN SRLRLWTKWV FAGVSLVGLI LWLALDTAQR PEQLIPFAGI 180
CMFILILFAC SKHHSAVSWR TVFSGLGLQF VFGILVIRTD LGYTVFQWLG EQVQIFLNYT 240
VAGSSFVFGD TLVKDVFAFQ ALPIIIFFGC VVSILYYLGL VQWVVQKVAW FLQITMGTTA 300
TETLAVAGNI FVGMTEAPLL IRPYLGDMTL SEIHAVMTGG FATISGTVLG AFIAFGVDAS 360
SLISASVMAA PCALASSKLA YPEVEESKFK SEEGVKLPRG KERNVLEAAS NGAVDAIGLA 420
TNVAANLIAF LAVLAFINAA LSWLGELVDI QGLTFQVICS YLLRPMVFMM GVEWTDCPMV 480
AEMVGIKFFI NEFVAYQQLS QYKNKRLSGM EEWIEGEKQW ISVRAEIITT FSLCGFANLS 540
SIGITLGGLT SIVPHRKSDL SKVVVRALFT GACVSLISAC MAGILYVPRG AEADCVSFPN 600
TSFTNRTYET YMCCRGLFQS TSLNGTNPPS FSGPWEDKEF SAMALTNCCG FYNNTVCA 659
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR008276--C_nuclsd_transpt
IPR018270--C_nuclsd_transpt_met_bac
IPR030212--CNT1/CNT2
IPR011657--CNT_C_dom
IPR002668--CNT_N_dom
IPR011642--Gate_dom
PROSITE
Pfam

PF07670--Gate
PF07662--Nucleos_tra2_C
PF01773--Nucleos_tra2_N
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005415--F:nucleoside:sodium symporter activity
GO:0015211--F:purine nucleoside transmembrane transporter activity
GO:0006139--P:nucleobase-containing compound metabolic process
GO:0015860--P:purine nucleoside transmembrane transport
GO:0055085--P:transmembrane transport