Tag |
Content |
dbPAF ID |
dbPAF-0001664 |
Uniprot Accession |
O43854; EDIL3_HUMAN; B2R763; O43855; Q5D094; Q8N610; |
Genbank Protein ID |
NP_001265571.1; NP_005702.3; |
Genbank Nucleotide ID |
NM_001278642.1; NM_005711.4; |
Protein Name |
EGF-like repeat and discoidin I-like domain-containing protein 3 |
Protein Synonyms/Alias |
Developmentally-regulated endothelial cell locus 1 protein;Integrin-binding protein DEL1; |
Gene Name |
EDIL3 |
Gene Synonyms/Alias |
DEL1; |
Organism |
Homo sapiens(Human) |
NCBI Taxa ID |
9606 |
Functional Description (View all) |
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.Functional Description
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
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Phosphorylation Sites
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dbPAF PTMs: 4 Position | Peptides | Source | References ( PMIDs ) |
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246 | SPEYIKSYKIAYSND | PhosphoSitePlus | 22135298 | 250 | IKSYKIAYSNDGKTW | PhosphoSitePlus;curated | 22135298; 22817900 | 260 | DGKTWAMYKVKGTNE | PhosphoSitePlus;curated | 22135298; 22817900 | 452 | NVIDPPIYARHIRIL | PhosphoSitePlus | 22135298 |
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Sequence (Fasta) | MKRSVAVWLL VGLSLGVPQF GKGDICDPNP CENGGICLPG LADGSFSCEC PDGFTDPNCS 60 SVVEVASDEE EPTSAGPCTP NPCHNGGTCE ISEAYRGDTF IGYVCKCPRG FNGIHCQHNI 120 NECEVEPCKN GGICTDLVAN YSCECPGEFM GRNCQYKCSG PLGIEGGIIS NQQITASSTH 180 RALFGLQKWY PYYARLNKKG LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP 240 EYIKSYKIAY SNDGKTWAMY KVKGTNEDMV FRGNIDNNTP YANSFTPPIK AQYVRLYPQV 300 CRRHCTLRME LLGCELSGCS EPLGMKSGHI QDYQITASSI FRTLNMDMFT WEPRKARLDK 360 QGKVNAWTSG HNDQSQWLQV DLLVPTKVTG IITQGAKDFG HVQFVGSYKL AYSNDGEHWT 420 VYQDEKQRKD KVFQGNFDND THRKNVIDPP IYARHIRILP WSWYGRITLR SELLGCTEEE 480
481Fasta Sequence
>O43854|EDIL3|Homo sapiens(Human) MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
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Keyword |
KW-0002--3D-structure KW-0025--Alternative splicing KW-0106--Calcium KW-0130--Cell adhesion KW-0181--Complete proteome KW-0217--Developmental protein KW-1015--Disulfide bond KW-0245--EGF-like domain KW-0325--Glycoprotein KW-0479--Metal-binding KW-1185--Reference proteome KW-0677--Repeat KW-0964--Secreted KW-0732--Signal
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Interpro |
IPR029828--EDIL-3 IPR001881--EGF-like_Ca-bd_dom IPR013032--EGF-like_CS IPR000742--EGF-like_dom IPR000152--EGF-type_Asp/Asn_hydroxyl_site IPR018097--EGF_Ca-bd_CS IPR000421--FA58C IPR008979--Galactose-bd-like
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PROSITE |
PS00010--ASX_HYDROXYL PS00022--EGF_1 PS01186--EGF_2 PS50026--EGF_3 PS01187--EGF_CA PS01285--FA58C_1 PS01286--FA58C_2 PS50022--FA58C_3
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Pfam |
PF00008--EGF PF00754--F5_F8_type_C
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Gene Ontology |
GO:0070062--C:extracellular exosome GO:1903561--C:extracellular vesicle GO:0005509--F:calcium ion binding GO:0005178--F:integrin binding GO:0007155--P:cell adhesion GO:0007275--P:multicellular organismal development GO:0010811--P:positive regulation of cell-substrate adhesion
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