dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001664
Uniprot Accession O43854; EDIL3_HUMAN; B2R763; O43855; Q5D094; Q8N610;
Genbank Protein ID NP_001265571.1; NP_005702.3;
Genbank Nucleotide ID NM_001278642.1; NM_005711.4;
Protein Name EGF-like repeat and discoidin I-like domain-containing protein 3
Protein Synonyms/Alias Developmentally-regulated endothelial cell locus 1 protein;Integrin-binding protein DEL1;
Gene Name EDIL3
Gene Synonyms/Alias DEL1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.
Phosphorylation Sites
dbPAF PTMs: 4
PositionPeptidesSourceReferences ( PMIDs )
246SPEYIKSYKIAYSNDPhosphoSitePlus22135298
250IKSYKIAYSNDGKTWPhosphoSitePlus;curated22135298; 22817900
260DGKTWAMYKVKGTNEPhosphoSitePlus;curated22135298; 22817900
452NVIDPPIYARHIRILPhosphoSitePlus22135298
Sequence
(Fasta)
MKRSVAVWLL VGLSLGVPQF GKGDICDPNP CENGGICLPG LADGSFSCEC PDGFTDPNCS 60
SVVEVASDEE EPTSAGPCTP NPCHNGGTCE ISEAYRGDTF IGYVCKCPRG FNGIHCQHNI 120
NECEVEPCKN GGICTDLVAN YSCECPGEFM GRNCQYKCSG PLGIEGGIIS NQQITASSTH 180
RALFGLQKWY PYYARLNKKG LINAWTAAEN DRWPWIQINL QRKMRVTGVI TQGAKRIGSP 240
EYIKSYKIAY SNDGKTWAMY KVKGTNEDMV FRGNIDNNTP YANSFTPPIK AQYVRLYPQV 300
CRRHCTLRME LLGCELSGCS EPLGMKSGHI QDYQITASSI FRTLNMDMFT WEPRKARLDK 360
QGKVNAWTSG HNDQSQWLQV DLLVPTKVTG IITQGAKDFG HVQFVGSYKL AYSNDGEHWT 420
VYQDEKQRKD KVFQGNFDND THRKNVIDPP IYARHIRILP WSWYGRITLR SELLGCTEEE 480
481
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0130--Cell adhesion
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1015--Disulfide bond
KW-0245--EGF-like domain
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted
KW-0732--Signal

Interpro

IPR029828--EDIL-3
IPR001881--EGF-like_Ca-bd_dom
IPR013032--EGF-like_CS
IPR000742--EGF-like_dom
IPR000152--EGF-type_Asp/Asn_hydroxyl_site
IPR018097--EGF_Ca-bd_CS
IPR000421--FA58C
IPR008979--Galactose-bd-like

PROSITE

PS00010--ASX_HYDROXYL
PS00022--EGF_1
PS01186--EGF_2
PS50026--EGF_3
PS01187--EGF_CA
PS01285--FA58C_1
PS01286--FA58C_2
PS50022--FA58C_3

Pfam

PF00008--EGF
PF00754--F5_F8_type_C

Gene Ontology

GO:0070062--C:extracellular exosome
GO:1903561--C:extracellular vesicle
GO:0005509--F:calcium ion binding
GO:0005178--F:integrin binding
GO:0007155--P:cell adhesion
GO:0007275--P:multicellular organismal development
GO:0010811--P:positive regulation of cell-substrate adhesion