dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001663
Uniprot Accession O43852; CALU_HUMAN; B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; O60456; Q6FHB9; Q96RL3; Q9NR43;
Genbank Protein ID NP_001124146.1; NP_001186600.1; NP_001186601.1; NP_001186602.1; NP_001210.1;
Genbank Nucleotide ID NM_001130674.2; NM_001199671.1; NM_001199672.1; NM_001199673.1; NM_001219.4;
Protein Name Calumenin
Protein Synonyms/Alias Crocalbin;IEF SSP 9302;
Gene Name CALU
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 18
PositionPeptidesSourceReferences ( PMIDs )
35VHHEPQLSDKVHNDAdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated19413330; 16381945; 23193290; 19060867; 22135298; 23917254
44KVHNDAQSFDYDHDAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18691976; 16381945; 23193290; 19362540; 20068231;
47NDAQSFDYDHDAFLGdbPTM 3.0;PhosphoSitePlus;curated19362540; 16381945; 23193290; 22135298; 25627689; 23917254;
60LGAEEAKTFDQLTPEPhosphoSitePlus;curated22135298; 25627689
65AKTFDQLTPEESKERdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 18691976; 16381945; 23193290; 20068231; 19413330;
69DQLTPEESKERLGKIdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated18767875; 16381945; 23193290; 18988627; 22135298; 25627689;
106FAQKRWIYEDVERQWdbPTM 3.0;PhosphoSitePlus;curated19362540; 21403953; 21447384; 16381945; 23193290; 22135298;
125LNEDGLVSWEEYKNAPhosphoSitePlus;curated22135298; 25627689; 24961811
177IATKEEFTAFLHPEEPhosphoSitePlus22135298
196KDIVVQETMEDIDKNPhosphoSitePlus;curated22135298; 23663014
224MYSHDGNTDEPEWVKPhosphoSitePlus22135298
254GKMDKEETKDWILPSPhosphoSitePlus;curated22135298; 23917254
261TKDWILPSDYDHAEAPhosphoSitePlus;curated22135298; 23917254; 20873877
263DWILPSDYDHAEAEAPhosphoSitePlus22135298
275AEARHLVYESDQNKDdbPTM 3.0;PhosphoSitePlus;curated21403953; 16381945; 23193290; 22135298; 24961811
277ARHLVYESDQNKDGKdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 25627689; 23186163
300KYDLFVGSQATDFGEdbPTM 3.0;Phospho.ELM 9.0;PhosphoSitePlus;curated22067460; 16381945; 23193290; 22135298; 25627689; 23663014
303LFVGSQATDFGEALVcurated23663014
Sequence
(Fasta)		MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQSFDYDHD AFLGAEEAKT 60
FDQLTPEESK ERLGKIVSKI DGDKDGFVTV DELKDWIKFA QKRWIYEDVE RQWKGHDLNE 120
DGLVSWEEYK NATYGYVLDD PDPDDGFNYK QMMVRDERRF KMADKDGDLI ATKEEFTAFL 180
HPEEYDYMKD IVVQETMEDI DKNADGFIDL EEYIGDMYSH DGNTDEPEWV KTEREQFVEF 240
RDKNRDGKMD KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS 300
QATDFGEALV RHDEF 316
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0703--Sarcoplasmic reticulum
KW-0964--Secreted
KW-0732--Signal
Interpro

IPR027239--Calumenin
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
PROSITE

PS00018--EF_HAND_1
PS50222--EF_HAND_2
Pfam

PF13202--EF-hand_5
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005576--C:extracellular region
GO:0005794--C:Golgi apparatus
GO:0042470--C:melanosome
GO:0016020--C:membrane
GO:0033018--C:sarcoplasmic reticulum lumen
GO:0005509--F:calcium ion binding
GO:0004857--F:enzyme inhibitor activity
GO:0007596--P:blood coagulation
GO:0014012--P:peripheral nervous system axon regeneration
GO:0030168--P:platelet activation
GO:0002576--P:platelet degranulation
GO:0014070--P:response to organic cyclic compound