dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001662
Uniprot Accession O43847; NRDC_HUMAN; A6NI41; O15241; O15242; Q5VUL0; Q96HB2; Q9NU57;
Genbank Protein ID NP_001095132.1; NP_001229290.1; NP_002516.2;
Genbank Nucleotide ID NM_001101662.1; NM_001242361.1; NM_002525.2;
Protein Name Nardilysin
Protein Synonyms/Alias N-arginine dibasic convertase;NRD convertase;NRD-C;
Gene Name NRD1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
58PGRNKAKSTCSCPDLPhosphoSitePlus;curated22135298; 25627689; 23090842
59GRNKAKSTCSCPDLQPhosphoSitePlus;curated22135298; 25627689; 23090842
61NKAKSTCSCPDLQPNPhosphoSitePlus;curated22135298; 25627689; 23917254; 23090842; 25262027
86ARLGADESEEEGRRGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 19415658; 20068231; 18988627;
94EEEGRRGSLSNAGDPdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 18707149; 19276368;
96EGRRGSLSNAGDPEIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 19690332; 19651622; 18988627;
106GDPEIVKSPSDPKQYPhosphoSitePlus;curated22135298; 25627689
108PEIVKSPSDPKQYRYPhosphoSitePlus22135298
314VEAVDSEYQLARPSDPhosphoSitePlus22135298
331RKEMLFGSLARPGHPPHOSIDA21081558
390QSKETLDTLEKWVTEdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 21081558; 22135298;
923NSEVTVYYQSGTRSLPhosphoSitePlus22135298
925EVTVYYQSGTRSLREPhosphoSitePlus22135298
927TVYYQSGTRSLREYTPhosphoSitePlus22135298
969YPTCRNTSGILGFSVPhosphoSitePlus22135298
Sequence
(Fasta)		MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM PGRNKAKSTC 60
SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD PEIVKSPSDP KQYRYIKLQN 120
GLQALLISDL SNMEGKTGNT TDDEEEEEVE EEEDDDEDSG AEIEDDDEEG FDDEDEFDDE 180
HDDDLDTEDN ELEELEERAE ARKKTTEKQS AAALCVGVGS FADPDDLPGL AHFLEHMVFM 240
GSLKYPDENG FDAFLKKHGG SDNASTDCER TVFQFDVQRK YFKEALDRWA QFFIHPLMIR 300
DAIDREVEAV DSEYQLARPS DANRKEMLFG SLARPGHPMG KFFWGNAETL KHEPRKNNID 360
THARLREFWM RYYSSHYMTL VVQSKETLDT LEKWVTEIFS QIPNNGLPRP NFGHLTDPFD 420
TPAFNKLYRV VPIRKIHALT ITWALPPQQQ HYRVKPLHYI SWLVGHEGKG SILSFLRKKC 480
WALALFGGNG ETGFEQNSTY SVFSISITLT DEGYEHFYEV AYTVFQYLKM LQKLGPEKRI 540
FEEIRKIEDN EFHYQEQTDP VEYVENMCEN MQLYPLQDIL TGDQLLFEYK PEVIGEALNQ 600
LVPQKANLVL LSGANEGKCD LKEKWFGTQY SIEDIENSWA ELWNSNFELN PDLHLPAENK 660
YIATDFTLKA FDCPETEYPV KIVNTPQGCL WYKKDNKFKI PKAYIRFHLI SPLIQKSAAN 720
VVLFDIFVNI LTHNLAEPAY EADVAQLEYK LVAGEHGLII RVKGFNHKLP LLFQLIIDYL 780
AEFNSTPAVF TMITEQLKKT YFNILIKPET LAKDVRLLIL EYARWSMIDK YQALMDGLSL 840
ESLLSFVKEF KSQLFVEGLV QGNVTSTESM DFLKYVVDKL NFKPLEQEMP VQFQVVELPS 900
GHHLCKVKAL NKGDANSEVT VYYQSGTRSL REYTLMELLV MHMEEPCFDF LRTKQTLGYH 960
VYPTCRNTSG ILGFSVTVGT QATKYNSEVV DKKIEEFLSS FEEKIENLTE EAFNTQVTAL 1020
IKLKECEDTH LGEEVDRNWN EVVTQQYLFD RLAHEIEALK SFSKSDLVNW FKAHRGPGSK 1080
MLSVHVVGYG KYELEEDGTP SSEDSNSSCE VMQLTYLPTS PLLADCIIPI TDIRAFTTTL 1140
NLLPYHKIVK 1151
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0732--Signal
KW-0862--Zinc
Interpro

IPR011249--Metalloenz_LuxS/M16
IPR011237--Pept_M16_dom
IPR011765--Pept_M16_N
IPR001431--Pept_M16_Zn_BS
IPR007863--Peptidase_M16_C
IPR032632--Peptidase_M16_M
PROSITE

PS00143--INSULINASE
Pfam

PF00675--Peptidase_M16
PF05193--Peptidase_M16_C
PF16187--Peptidase_M16_M
Gene Ontology

GO:0009986--C:cell surface
GO:0005829--C:cytosol
GO:0048408--F:epidermal growth factor binding
GO:0004222--F:metalloendopeptidase activity
GO:0008270--F:zinc ion binding
GO:0016477--P:cell migration
GO:0008283--P:cell proliferation
GO:0007528--P:neuromuscular junction development
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
GO:0016485--P:protein processing
GO:0006508--P:proteolysis
GO:0052548--P:regulation of endopeptidase activity