dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001661
Uniprot Accession O43837; IDH3B_HUMAN; B2RDR1; D3DVX2; D3DVX3; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99;
Genbank Protein ID NP_008830.2; NP_777280.1;
Genbank Nucleotide ID NM_006899.3; NM_174855.2;
Protein Name Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
Protein Synonyms/Alias Isocitric dehydrogenase subunit beta;NAD(+)-specific ICDH subunit beta;
Gene Name IDH3B
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
Phosphorylation Sites
 dbPAF PTMs: 6
PositionPeptidesSourceReferences ( PMIDs )
172EQTEGEYSSLEHESAPhosphoSitePlus22135298
178YSSLEHESARGVIECPhosphoSitePlus22135298
323GRNIANPTAMLLSASPHOSIDA21081558
330TAMLLSASNMLRHLNPhosphoSitePlus22135298
366RTRDMGGYSTTTDFIPhosphoSitePlus;curated22135298; 22817900
375TTTDFIKSVIGHLQTPhosphoSitePlus22135298
Sequence
(Fasta)		MAALSGVRWL TRALVSAGNP GAWRGLSTSA AAHAASRSQA EDVRVEGSFP VTMLPGDGVG 60
PELMHAVKEV FKAAAVPVEF QEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIHTPME 120
YKGELASYDM RLRRKLDLFA NVVHVKSLPG YMTRHNNLDL VIIREQTEGE YSSLEHESAR 180
GVIECLKIVT RAKSQRIAKF AFDYATKKGR GKVTAVHKAN IMKLGDGLFL QCCEEVAELY 240
PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY 300
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT 360
RDMGGYSTTT DFIKSVIGHL QTKGS 386
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0520--NAD
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0682--Retinitis pigmentosa
KW-0809--Transit peptide
KW-0816--Tricarboxylic acid cycle
Interpro

IPR019818--IsoCit/isopropylmalate_DH_CS
IPR001804--Isocitrate/isopropylmalate_DH
IPR004434--Isocitrate_DH_NAD
IPR024084--IsoPropMal-DH-like_dom
PROSITE

PS00470--IDH_IMDH
Pfam

PF00180--Iso_dh
Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0009055--F:electron carrier activity
GO:0004449--F:isocitrate dehydrogenase (NAD+) activity
GO:0000287--F:magnesium ion binding
GO:0051287--F:NAD binding
GO:0006103--P:2-oxoglutarate metabolic process
GO:0044237--P:cellular metabolic process
GO:0006102--P:isocitrate metabolic process
GO:0006734--P:NADH metabolic process
GO:0044281--P:small molecule metabolic process
GO:0006099--P:tricarboxylic acid cycle