dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001659
Uniprot Accession O43829; ZBT14_HUMAN; O00403; Q2TB80;
Genbank Protein ID NP_001137295.1; NP_001230631.1; NP_001230633.1; NP_003400.2;
Genbank Nucleotide ID NM_001143823.2; NM_001243702.1; NM_001243704.1; NM_003409.4;
Protein Name Zinc finger and BTB domain-containing protein 14
Protein Synonyms/Alias Zinc finger protein 161 homolog;Zfp-161;Zinc finger protein 478;Zinc finger protein 5 homolog;ZF5;Zfp-5;hZF5;
Gene Name ZBTB14
Gene Synonyms/Alias ZFP161;ZNF478;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
74KLEVDSSSVIEIDFLPhosphoSitePlus22135298
131CSQKRDVSSPDENNGPhosphoPep 2.0;curated19060867; 25627689; 20873877; 26074081
132SQKRDVSSPDENNGQPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25627689; 20873877; 25262027
190PSQEDGKSPTTTLRVPhosphoSitePlus;curated22135298; 25627689; 20363803; 26074081
192QEDGKSPTTTLRVQEcurated25627689
207AILKELGSEEVRKVNcurated25003641
222CYGQEVESMETPESKPhosphoSitePlus;curated22135298; 25627689
225QEVESMETPESKDLGPhosphoSitePlus;curated22135298; 25627689
228ESMETPESKDLGSQTPhosphoSitePlus22135298
233PESKDLGSQTPQALTPhosphoSitePlus;curated22135298; 25627689
235SKDLGSQTPQALTFNPhosphoPep 2.0;PhosphoSitePlus;curated19060867; 22135298; 25850435; 25627689; 23090842; 22817900;
253SEVKDEQTPGWTTAAPhosphoSitePlus;curated22135298; 25627689; 23090842
257DEQTPGWTTAASDMKPhosphoSitePlus22135298
285ACQACGKTFSDEGRLdbPTM 3.0;curated18187866; 16381945; 23193290; 22817900
287QACGKTFSDEGRLRKdbPTM 3.0;curated18187866; 16381945; 23193290; 22817900
300RKHEKLHTADRPFVCPhosphoSitePlus;curated22135298; 25627689
328KEHLKIHTGYKPYSCPhosphoSitePlus22135298
356KKHERVHSNERPFACPhosphoSitePlus;curated22135298; 25627689
393EKPFVCGSCTKAFAKcurated25627689
419HSERKQVTPSAIQSEPhosphoSitePlus22135298
Sequence
(Fasta)		MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY 60
FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL 120
DKLCSQKRDV SSPDENNGQS KSKYCLKINR PIGDAADTQD DDVEEIGDQD DSPSDDTVEG 180
TPPSQEDGKS PTTTLRVQEA ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT 240
FNDGMSEVKD EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT 300
ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK HERVHSNERP 360
FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK ASDLKRHENN MHSERKQVTP 420
SAIQSETEQL QAAAMAAEAE QQLETIACS
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--POZ_dom
IPR007087--Znf_C2H2
IPR015880--Znf_C2H2-like
IPR013087--Znf_C2H2/integrase_DNA-bd
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
PF00096--zf-C2H2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated