| Tag |
Content |
| dbPAF ID |
dbPAF-0001657 |
| Uniprot Accession |
O43826; G6PT1_HUMAN; O96016; Q5J7V4; Q9UI19; Q9UNS4;
|
| Genbank Protein ID |
NP_001157749.1; NP_001157750.1; NP_001157751.1; NP_001157752.1; NP_001458.1;
|
| Genbank Nucleotide ID |
NM_001164277.1; NM_001164278.1; NM_001164279.1; NM_001164280.1; NM_001467.5;
|
| Protein Name |
Glucose-6-phosphate translocase |
| Protein Synonyms/Alias |
Glucose-5-phosphate transporter;Solute carrier family 37 member 4;Transformation-related gene 19 protein;TRG-19; |
| Gene Name |
SLC37A4 |
| Gene Synonyms/Alias |
G6PT;G6PT1;PRO0685;TRG19; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.Functional Description
Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. |
Phosphorylation Sites
|
dbPAF PTMs: 2 |
Sequence
(Fasta) | MAAQGYGYYR TVIFSAMFGG YSLYYFNRKT FSFVMPSLVE EIPLDKDDLG FITSSQSAAY 60
AISKFVSGVL SDQMSARWLF SSGLLLVGLV NIFFAWSSTV PVFAALWFLN GLAQGLGWPP 120
CGKVLRKWFE PSQFGTWWAI LSTSMNLAGG LGPILATILA QSYSWRSTLA LSGALCVVVS 180
FLCLLLIHNE PADVGLRNLD PMPSEGKKGS LKEESTLQEL LLSPYLWVLS TGYLVVFGVK 240
TCCTDWGQFF LIQEKGQSAL VGSSYMSALE VGGLVGSIAA GYLSDRAMAK AGLSNYGNPR 300
HGLLLFMMAG MTVSMYLFRV TVTSDSPKLW ILVLGAVFGF SSYGPIALFG VIANESAPPN 360
LCGTSHAIVG LMANVGGFLA GLPFSTIAKH YSWSTAFWVA EVICAASTAA FFLLRNIRTK 420
MGRVSKKAE
Fasta Sequence
>O43826|SLC37A4|Homo sapiens(Human)
MAAQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTKMGRVSKKAE
|
| Keyword |
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0322--Glycogen storage disease
KW-0472--Membrane
KW-1185--Reference proteome
KW-0762--Sugar transport
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
|
| Interpro |
IPR011701--MFS
IPR020846--MFS_dom
IPR021159--Sugar-P_transporter_CS
IPR000849--Sugar_P_transporter
|
| PROSITE |
PS00942--GLPT
PS50850--MFS
|
| Pfam |
PF07690--MFS_1
|
| Gene Ontology |
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0015152--F:glucose-6-phosphate transmembrane transporter activity
GO:0005215--F:transporter activity
GO:0005975--P:carbohydrate metabolic process
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0015758--P:glucose transport
GO:0015760--P:glucose-6-phosphate transport
GO:0008645--P:hexose transport
GO:0098779--P:mitophagy in response to mitochondrial depolarization
GO:0002230--P:positive regulation of defense response to virus by host
GO:0044281--P:small molecule metabolic process
GO:0055085--P:transmembrane transport
GO:0006810--P:transport
GO:0098792--P:xenophagy
|
