dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001654
Uniprot Accession O43823; AKAP8_HUMAN;
Genbank Protein ID NP_005849.1;
Genbank Nucleotide ID NM_005858.3;
Protein Name A-kinase anchor protein 8
Protein Synonyms/Alias
Gene Name AKAP8
Gene Synonyms/Alias AKAP95;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).
Phosphorylation Sites
 dbPAF PTMs: 30 (View all)
PositionPeptidesSourceReferences ( PMIDs )
51SVTTGATYSYGPASWPhosphoSitePlus22135298
53TTGATYSYGPASWEAPhosphoSitePlus22135298
80PAMHMASYGPEPCTDPhosphoSitePlus22135298
91PCTDNSDSLIAKINQcurated25627689
112KEGGRGGSGGGGEGIdbPTM 3.0;Phospho.ELM 9.0;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 16381945; 23193290; 21406692; 19060867; 22135298;
136QPFESYDSRPCLPEHPhosphoSitePlus22135298
146CLPEHNPYRPSYSYDPhosphoSitePlus22135298
149EHNPYRPSYSYDYEFPhosphoSitePlus22135298
150HNPYRPSYSYDYEFDPhosphoSitePlus22135298
152PYRPSYSYDYEFDLGdbPTM 3.0;PhosphoSitePlus;curated18698806; 16381945; 23193290; 22135298; 22817900
154RPSYSYDYEFDLGSDPhosphoSitePlus22135298
170NGSFGGQYSECRDPAPhosphoSitePlus22135298
182DPARERGSLDGFMRGPhosphoSitePlus;curated22135298; 23186163
199QGRFQDRSNPGTFMRPhosphoSitePlus;curated22135298; 23917254
229TPWNELNYVGGRGLGdbPTM 3.0;PhosphoSitePlus;curated17360941; 16381945; 23193290; 22135298; 22817900
239GRGLGGPSPSRPPPScurated26074081
301DRFGPDGTGRKRKQFPhosphoSitePlus22135298
311KRKQFQLYEEPDTKLdbPTM 3.0;PhosphoSitePlus21403953; 21447384; 16381945; 23193290; 22135298
323TKLARVDSEGDFSENdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 19413330; 19690332; 16381945; 23193290;
328VDSEGDFSENDDAAGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 17081983; 18669648; 18691976; 19413330; 19690332;
Sequence
(Fasta)		MDQGYGGYGA WSAGPANTQG AYGTGVASWQ GYENYNYYGA QNTSVTTGAT YSYGPASWEA 60
AKANDGGLAA GAPAMHMASY GPEPCTDNSD SLIAKINQRL DMMSKEGGRG GSGGGGEGIQ 120
DRESSFRFQP FESYDSRPCL PEHNPYRPSY SYDYEFDLGS DRNGSFGGQY SECRDPARER 180
GSLDGFMRGR GQGRFQDRSN PGTFMRSDPF VPPAASSEPL STPWNELNYV GGRGLGGPSP 240
SRPPPSLFSQ SMAPDYGVMG MQGAGGYDST MPYGCGRSQP RMRDRDRPKR RGFDRFGPDG 300
TGRKRKQFQL YEEPDTKLAR VDSEGDFSEN DDAAGDFRSG DEEFKGEDEL CDSGRQRGEK 360
EDEDEDVKKR REKQRRRDRT RDRAADRIQF ACSVCKFRSF DDEEIQKHLQ SKFHKETLRF 420
ISTKLPDKTV EFLQEYIVNR NKKIEKRRQE LMEKETAKPK PDPFKGIGQE HFFKKIEAAH 480
CLACDMLIPA QPQLLQRHLH SVDHNHNRRL AAEQFKKTSL HVAKSVLNNR HIVKMLEKYL 540
KGEDPFTSET VDPEMEGDDN LGGEDKKETP EEVAADVLAE VITAAVRAVD GEGAPAPESS 600
GEPAEDEGPT DTAEAGSDPQ AEQLLEEQVP CGTAHEKGVP KARSEAAEAG NGAETMAAEA 660
ESAQTRVAPA PAAADAEVEQ TDAESKDAVP TE 693
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007071--AKAP95
IPR015880--Znf_C2H2-like
PROSITE
Pfam

PF04988--AKAP95
Gene Ontology

GO:0001939--C:female pronucleus
GO:0005794--C:Golgi apparatus
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003690--F:double-stranded DNA binding
GO:0044822--F:poly(A) RNA binding
GO:0034237--F:protein kinase A regulatory subunit binding
GO:0008270--F:zinc ion binding
GO:0007067--P:mitotic nuclear division
GO:0007165--P:signal transduction