dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001645
Uniprot Accession O43795; MYO1B_HUMAN; O43794; Q7Z6L5;
Genbank Protein ID NP_001123630.1; NP_001155291.1; NP_036355.2; XP_005246629.1; XP_006712599.1; XP_011509515.1;
Genbank Nucleotide ID NM_001130158.1; NM_001161819.1; NM_012223.3; XM_005246572.1; XM_006712536.1; XM_011511213.1;
Protein Name Unconventional myosin-Ib
Protein Synonyms/Alias MYH-1c;Myosin I alpha;MMI-alpha;MMIa;
Gene Name MYO1B
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.
Phosphorylation Sites
 dbPAF PTMs: 29 (View all)
PositionPeptidesSourceReferences ( PMIDs )
60ISVNPYRSLPIYSPEPhosphoSitePlus;UniProt;curated22135298; 24275569; 25850435
65YRSLPIYSPEKVEEYPhosphoSitePlus22135298
107KDQCILITGESGAGKPhosphoSitePlus22135298
110CILITGESGAGKTEAPhosphoSitePlus22135298
115GESGAGKTEASKLVMPhosphoSitePlus22135298
118GAGKTEASKLVMSYVPhosphoSitePlus22135298
145VKEQLLQSNPVLEAFPhosphoSitePlus22135298
213HVFYQLLSGASEELLdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
216YQLLSGASEELLNKLdbPTM 3.0;HPRD 9;curated20068231; 16381945; 23193290; 18988627
232LERDFSRYNYLSLDScurated20071362
239YNYLSLDSAKVNGVDcurated20071362
325SVLERAFSFRTVEAKPhosphoSitePlus;curated22135298; 25627689
504SRFLNDTSLPHSCFRcurated24961811
508NDTSLPHSCFRIQHYPHOSIDA21081558
535DKNNDLLYRDLSQAMPhosphoSitePlus22135298
569INLKRPPTAGSQFKAPhosphoSitePlus22135298
577AGSQFKASVATLMKNdbPTM 3.0;PhosphoSitePlus;curated21406692; 16381945; 23193290; 22135298; 22817900
580QFKASVATLMKNLQTPhosphoSitePlus22135298
789AVTTIAAYWHGTQARPhosphoSitePlus22135298
793IAAYWHGTQARRELRdbPTM 3.0;PhosphoSitePlus20068231; 16381945; 23193290; 22135298
Sequence
(Fasta)		MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS 60
LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL 120
VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP 180
LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA 240
KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 300
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL 360
FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL 420
KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN 480
QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ 540
AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 600
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA 660
RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC 720
RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK 780
EAVTTIAAYW HGTQARRELR RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA 840
VAVIWAYWLG LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP 900
SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD KKALYPSSVG 960
QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN GKSTSRIFLL TNNNLLLADQ 1020
KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH LKEGSEAASK GDFLFSSDHL IEMATKLYRT 1080
TLSQTKQKLN IEISDEFLVQ FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP 1137
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0505--Motor protein
KW-0518--Myosin
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR000048--IQ_motif_EF-hand-BS
IPR001609--Myosin_head_motor_dom
IPR010926--Myosin_TH1
IPR027417--P-loop_NTPase
PROSITE

PS50096--IQ
PS51456--MYOSIN_MOTOR
PS51757--TH1
Pfam

PF00612--IQ
PF00063--Myosin_head
PF06017--Myosin_TH1
Gene Ontology

GO:0005884--C:actin filament
GO:0005903--C:brush border
GO:0071944--C:cell periphery
GO:0005737--C:cytoplasm
GO:0005769--C:early endosome
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0030175--C:filopodium
GO:0016459--C:myosin complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0051015--F:actin filament binding
GO:0030898--F:actin-dependent ATPase activity
GO:0005524--F:ATP binding
GO:0000146--F:microfilament motor activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0051017--P:actin filament bundle assembly
GO:0007015--P:actin filament organization
GO:0030048--P:actin filament-based movement
GO:0006892--P:post-Golgi vesicle-mediated transport