dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001642
Uniprot Accession O43781; DYRK3_HUMAN; D3DT79; Q7Z752; Q9HBY6; Q9HBY7;
Genbank Protein ID NP_001004023.1; NP_003573.2; XP_005273372.1; XP_005273373.1; XP_006711639.1;
Genbank Nucleotide ID NM_001004023.1; NM_003582.2; XM_005273315.3; XM_005273316.2; XM_006711576.2;
Protein Name Dual specificity tyrosine-phosphorylation-regulated kinase 3
Protein Synonyms/Alias Regulatory erythroid kinase;REDK;
Gene Name DYRK3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling.
Phosphorylation Sites
 dbPAF PTMs: 15
PositionPeptidesSourceReferences ( PMIDs )
106TIQSDGISDSEKCSPcurated25627689
209RDHLAYRYEVLKIIGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated15592455; 16381945; 23193290; 18988627; 22135298; 22817900
350LKHHGRSSTKVIDFGPhosphoSitePlus22135298
351KHHGRSSTKVIDFGSPhosphoSitePlus22135298
367CFEYQKLYTYIQSRFdbPTM 3.0;PhosphoSitePlus;curated18083107; 16381945; 23193290; 22135298; 22817900
368FEYQKLYTYIQSRFYPhosphoSitePlus22135298
369EYQKLYTYIQSRFYRdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 19534553; 16381945; 23193290; 17360941; 18180459;
372KLYTYIQSRFYRAPEPhosphoSitePlus22135298
451NSKGIPRYCSVTTQAPhosphoSitePlus22135298
453KGIPRYCSVTTQADGPhosphoSitePlus22135298
455IPRYCSVTTQADGRVPhosphoSitePlus22135298
456PRYCSVTTQADGRVVPhosphoSitePlus22135298
469VVLVGGRSRRGKKRGPhosphoSitePlus22135298
532SVPRPLTTIDKVSGKPhosphoSitePlus22135298
537LTTIDKVSGKRVVNPPhosphoSitePlus22135298
Sequence
(Fasta)		MGGTARGPGR KDAGPPGAGL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVL CNPSEPPPPR 60
RLNMTTEQFT GDHTQHFLDG GEMKVEQLFQ EFGNRKSNTI QSDGISDSEK CSPTVSQGKS 120
SDCLNTVKSN SSSKAPKVVP LTPEQALKQY KHHLTAYEKL EIINYPEIYF VGPNAKKRHG 180
VIGGPNNGGY DDADGAYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV 240
RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK 300
KNKFQGFSVQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKHHGRSS TKVIDFGSSC 360
FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC 420
MMELLGMPPP KLLEQSKRAK YFINSKGIPR YCSVTTQADG RVVLVGGRSR RGKKRGPPGS 480
KDWGTALKGC DDYLFIEFLK RCLHWDPSAR LTPAQALRHP WISKSVPRPL TTIDKVSGKR 540
VVNPASAFQG LGSKLPPVVG IANKLKANLM SETNGSIPLC SVLPKLIS 589
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR002290--Ser/Thr_dual-sp_kinase
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
Pfam

PF00069--Pkinase
Gene Ontology

GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0030218--P:erythrocyte differentiation
GO:0006468--P:protein phosphorylation