dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001639
Uniprot Accession O43768; ENSA_HUMAN; A8K1Z9; E9PB69; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0;
Genbank Protein ID NP_004427.1; NP_996925.1; NP_996926.1; NP_996927.1; NP_996928.1; NP_996929.1; NP_996930.1; NP_997051.1;
Genbank Nucleotide ID NM_004436.2; NM_207042.1; NM_207043.1; NM_207044.1; NM_207045.1; NM_207046.1; NM_207047.1; NM_207168.1;
Protein Name Alpha-endosulfine
Protein Synonyms/Alias ARPP-19e;
Gene Name ENSA
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Phosphorylation Sites
 dbPAF PTMs: 16
PositionPeptidesSourceReferences ( PMIDs )
2------MSQKQEEENdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 19362540; 20068231; 20164059;
14EENPAEETGEEKQDTPhosphoSitePlus;curated22135298; 23186163
21TGEEKQDTQEKEGILPhosphoSitePlus;curated22135298; 23186163
41EAKLKAKYPSLGQKPPhosphoSitePlus;curated22135298; 23917254; 26074081
43KLKAKYPSLGQKPGGdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17287340; 16381945; 23193290; 22115753; 18988627; 19060867;
51LGQKPGGSDFLMKRLPhosphoSitePlus22135298
64RLQKGQKYFDSGDYNdbPTM 3.0;PhosphoPep 2.0;PhosphoSitePlus;curated18083107; 18180459; 19901323; 20562096; 21403953; 21447384;
67KGQKYFDSGDYNMAKdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 18088087; 16381945; 23193290; 16674116; 17494752;
70KYFDSGDYNMAKAKMdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated17287340; 19534553; 16381945; 23193290; 17360941; 18083107;
84MKNKQLPSAGPDKNLPHOSIDA;PhosphoSitePlus21081558; 22135298
93GPDKNLVTGDHIPTPPhosphoSitePlus22135298
99VTGDHIPTPQDLPQRPhosphoSitePlus;curated22135298; 25627689; 23882029; 23898821; 26074081
108QDLPQRKSSLVTSKLdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17924679; 16381945; 23193290; 18988627; 19060867; 22135298;
109DLPQRKSSLVTSKLAdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated17924679; 18973346; 16381945; 23193290; 20068231; 20166139;
112QRKSSLVTSKLAGGQdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17924679; 16381945; 23193290; 18988627; 19060867; 22135298;
113RKSSLVTSKLAGGQVdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated17924679; 16381945; 23193290; 19651622; 18988627; 19060867;
Sequence
(Fasta)		MSQKQEEENP AEETGEEKQD TQEKEGILPE RAEEAKLKAK YPSLGQKPGG SDFLMKRLQK 60
GQKYFDSGDY NMAKAKMKNK QLPSAGPDKN LVTGDHIPTP QDLPQRKSSL VTSKLAGGQV 120
E 122
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0650--Protein phosphatase inhibitor
KW-1185--Reference proteome
Interpro

IPR006760--Endosulphine
PROSITE
Pfam

PF04667--Endosulfine
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0008200--F:ion channel inhibitor activity
GO:0019212--F:phosphatase inhibitor activity
GO:0019870--F:potassium channel inhibitor activity
GO:0051721--F:protein phosphatase 2A binding
GO:0004864--F:protein phosphatase inhibitor activity
GO:0008601--F:protein phosphatase type 2A regulator activity
GO:0005102--F:receptor binding
GO:0051301--P:cell division
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0043086--P:negative regulation of catalytic activity
GO:0050796--P:regulation of insulin secretion
GO:0034047--P:regulation of protein phosphatase type 2A activity
GO:0009749--P:response to glucose
GO:0007584--P:response to nutrient
GO:0006810--P:transport