dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001638
Uniprot Accession O43766; LIAS_HUMAN; A8K873; C9JCF6; Q8IV62;
Genbank Protein ID NP_001265519.1; NP_001265520.1; NP_001265521.1; NP_006850.2; NP_919433.1;
Genbank Nucleotide ID NM_001278590.1; NM_001278591.1; NM_001278592.1; NM_006859.3; NM_194451.2;
Protein Name Lipoyl synthase, mitochondrial
Protein Synonyms/Alias Lipoate synthase;LS;Lip-syn;Lipoic acid synthase;
Gene Name LIAS
Gene Synonyms/Alias LAS;HUSSY-01;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
20GPRVFGRYFCSPVRPPhosphoSitePlus22135298
23VFGRYFCSPVRPLSSPhosphoSitePlus22135298
Sequence
(Fasta)		MSLRCGDAAR TLGPRVFGRY FCSPVRPLSS LPDKKKELLQ NGPDLQDFVS GDLADRSTWD 60
EYKGNLKRQK GERLRLPPWL KTEIPMGKNY NKLKNTLRNL NLHTVCEEAR CPNIGECWGG 120
GEYATATATI MLMGDTCTRG CRFCSVKTAR NPPPLDASEP YNTAKAIAEW GLDYVVLTSV 180
DRDDMPDGGA EHIAKTVSYL KERNPKILVE CLTPDFRGDL KAIEKVALSG LDVYAHNVET 240
VPELQSKVRD PRANFDQSLR VLKHAKKVQP DVISKTSIML GLGENDEQVY ATMKALREAD 300
VDCLTLGQYM QPTRRHLKVE EYITPEKFKY WEKVGNELGF HYTASGPLVR SSYKAGEFFL 360
KNLVAKRKTK DL 373
Keyword

KW-0004--4Fe-4S
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0408--Iron
KW-0411--Iron-sulfur
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0809--Transit peptide
Interpro

IPR013785--Aldolase_TIM
IPR006638--Elp3/MiaB/NifB
IPR031691--LIAS_N
IPR003698--Lipoyl_synth
IPR007197--rSAM
PROSITE
Pfam

PF16881--LIAS_N
PF04055--Radical_SAM
Gene Ontology

GO:0005739--C:mitochondrion
GO:0051539--F:4 iron, 4 sulfur cluster binding
GO:0016992--F:lipoate synthase activity
GO:0046872--F:metal ion binding
GO:0006954--P:inflammatory response
GO:0009107--P:lipoate biosynthetic process
GO:0001843--P:neural tube closure
GO:0009249--P:protein lipoylation
GO:0032496--P:response to lipopolysaccharide
GO:0006979--P:response to oxidative stress