dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001637
Uniprot Accession O43765; SGTA_HUMAN; D6W610; Q6FIA9; Q9BTZ9;
Genbank Protein ID NP_003012.1; XP_011526480.1;
Genbank Nucleotide ID NM_003021.3; XM_011528178.1;
Protein Name Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Protein Synonyms/Alias Alpha-SGT;Vpu-binding protein;UBP;
Gene Name SGTA
Gene Synonyms/Alias SGT;SGT1;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
Phosphorylation Sites
 dbPAF PTMs: 20
PositionPeptidesSourceReferences ( PMIDs )
9DNKKRLAYAIIQFLHPhosphoSitePlus22135298
77EMPQDLRSPARTPPSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 20068231; 20363803;
81DLRSPARTPPSEEDSdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 19690332; 16381945; 23193290; 19362540; 19664995;
84SPARTPPSEEDSAEAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 17081983; 18988627; 21081558;
88TPPSEEDSAEAERLKPHOSIDA;curated21081558; 26074081; 24667141
141AYSKLGNYAGAVQDCPhosphoSitePlus22135298
158AICIDPAYSKAYGRMdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
159ICIDPAYSKAYGRMGdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20068231; 16381945; 23193290; 18988627; 22135298; 22817900
162DPAYSKAYGRMGLALPhosphoSitePlus22135298
171RMGLALSSLNKHVEAPHOSIDA;PhosphoSitePlus21081558; 22135298
194ELDPDNETYKSNLKIcurated26074081
195LDPDNETYKSNLKIAcurated26074081
211LKLREAPSPTGGVGScurated26074081
213LREAPSPTGGVGSFDcurated26074081
266GTPGTSPSQNDLASLcurated26074081
297ELIEQLRSQIRSRTPdbPTM 3.0;PhosphoSitePlus;curated20736484; 16381945; 23193290; 22135298; 25627689; 23898821;
301QLRSQIRSRTPSASNdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 18669648; 16381945; 23193290; 20736484; 21406692;
303RSQIRSRTPSASNDDdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated15302935; 18669648; 16381945; 23193290; 19690332; 20068231;
305QIRSRTPSASNDDQQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated16964243; 17081983; 18669648; 19690332; 16381945; 23193290;
307RSRTPSASNDDQQE-dbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20562096; 20736484; 16381945; 23193290; 19651622; 18988627;
Sequence
(Fasta)		MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE 60
IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL 120
NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA 180
YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN 240
PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR 300
SRTPSASNDD QQE 314
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0143--Chaperone
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0945--Host-virus interaction
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
Interpro

IPR032374--SGTA_dimer
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF16546--SGTA_dimer
PF00515--TPR_1
PF13414--TPR_11
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:1904288--F:BAT3 complex binding
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process