dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001636
Uniprot Accession O43763; TLX2_HUMAN; Q9UD56; Q9UQ48;
Genbank Protein ID NP_057254.1;
Genbank Nucleotide ID NM_016170.4;
Protein Name T-cell leukemia homeobox protein 2
Protein Synonyms/Alias Homeobox protein Hox-11L1;Neural crest homeobox protein;
Gene Name TLX2
Gene Synonyms/Alias HOX11L1;NCX;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
181RRFLRQKYLASAERAPhosphoSitePlus22135298
184LRQKYLASAERAALAPhosphoSitePlus22135298
Sequence
(Fasta)		MEPGMLGPHN LPHHEPISFG IDQILSGPET PGGGLGLGRG GQGHGENGAF SGGYHGASGY 60
GPAGSLAPLP GSSGVGPGGV IRVPAHRPLP VPPPAGGAPA VPGPSGLGGA GGLAGLTFPW 120
MDSGRRFAKD RLTAALSPFS GTRRIGHPYQ NRTPPKRKKP RTSFSRSQVL ELERRFLRQK 180
YLASAERAAL AKALRMTDAQ VKTWFQNRRT KWRRQTAEER EAERHRAGRL LLHLQQDALP 240
RPLRPPLPPD PLCLHNSSLF ALQNLQPWAE DNKVASVSGL ASVV 285
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0371--Homeobox
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR017970--Homeobox_CS
IPR001356--Homeobox_dom
IPR020479--Homeobox_metazoa
IPR009057--Homeodomain-like
PROSITE

PS00027--HOMEOBOX_1
PS50071--HOMEOBOX_2
Pfam

PF00046--Homeobox
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0043565--F:sequence-specific DNA binding
GO:0048484--P:enteric nervous system development
GO:0001707--P:mesoderm formation
GO:0050774--P:negative regulation of dendrite morphogenesis
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated