| Tag |
Content |
| dbPAF ID |
dbPAF-0001630 |
| Uniprot Accession |
O43747; AP1G1_HUMAN; O75709; O75842; Q9UG09; Q9Y3U4;
|
| Genbank Protein ID |
NP_001025178.1; NP_001119.3;
|
| Genbank Nucleotide ID |
NM_001030007.1; NM_001128.5;
|
| Protein Name |
AP-1 complex subunit gamma-1 |
| Protein Synonyms/Alias |
Adaptor protein complex AP-1 subunit gamma-1;Adaptor-related protein complex 1 subunit gamma-1;Clathrin assembly protein complex 1 gamma-1 large chain;Gamma1-adaptin;Golgi adaptor HA1/AP1 adaptin subunit gamma-1; |
| Gene Name |
AP1G1 |
| Gene Synonyms/Alias |
ADTG;CLAPG1; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.Functional Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. |
Phosphorylation Sites
|
dbPAF PTMs: 9 |
Sequence
(Fasta) | MPAPIRLREL IRTIRTARTQ AEEREMIQKE CAAIRSSFRE EDNTYRCRNV AKLLYMHMLG 60
YPAHFGQLEC LKLIASQKFT DKRIGYLGAM LLLDERQDVH LLMTNCIKND LNHSTQFVQG 120
LALCTLGCMG SSEMCRDLAG EVEKLLKTSN SYLRKKAALC AVHVIRKVPE LMEMFLPATK 180
NLLNEKNHGV LHTSVVLLTE MCERSPDMLA HFRKLVPQLV RILKNLIMSG YSPEHDVSGI 240
SDPFLQVRIL RLLRILGRND DDSSEAMNDI LAQVATNTET SKNVGNAILY ETVLTIMDIK 300
SESGLRVLAI NILGRFLLNN DKNIRYVALT SLLKTVQTDH NAVQRHRSTI VDCLKDLDVS 360
IKRRAMELSF ALVNGNNIRG MMKELLYFLD SCEPEFKADC ASGIFLAAEK YAPSKRWHID 420
TIMRVLTTAG SYVRDDAVPN LIQLITNSVE MHAYTVQRLY KAILGDYSQQ PLVQVAAWCI 480
GEYGDLLVSG QCEEEEPIQV TEDEVLDILE SVLISNMSTS VTRGYALTAI MKLSTRFTCT 540
VNRIKKVVSI YGSSIDVELQ QRAVEYNALF KKYDHMRSAL LERMPVMEKV TTNGPTEIVQ 600
TNGETEPAPL ETKPPPSGPQ PTSQANDLLD LLGGNDITPV IPTAPTSKPS SAGGELLDLL 660
GDINLTGAPA AAPAPASVPQ ISQPPFLLDG LSSQPLFNDI AAGIPSITAY SKNGLKIEFT 720
FERSNTNPSV TVITIQASNS TELDMTDFVF QAAVPKTFQL QLLSPSSSIV PAFNTGTITQ 780
VIKVLNPQKQ QLRMRIKLTY NHKGSAMQDL AEVNNFPPQS WQ
823Fasta Sequence
>O43747|AP1G1|Homo sapiens(Human)
MPAPIRLRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAALCAVHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLISNMSTSVTRGYALTAIMKLSTRFTCTVNRIKKVVSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDLLGGNDITPVIPTAPTSKPSSAGGELLDLLGDINLTGAPAAAPAPASVPQISQPPFLLDGLSSQPLFNDIAAGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDMTDFVFQAAVPKTFQLQLLSPSSSIVPAFNTGTITQVIKVLNPQKQQLRMRIKLTYNHKGSAMQDLAEVNNFPPQSWQ
|
| Keyword |
KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
|
| Interpro |
IPR017107--AP1_complex_gsu
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR002553--Clathrin/coatomer_adapt-like_N
IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
|
| PROSITE |
PS50180--GAE
|
| Pfam |
PF01602--Adaptin_N
PF02883--Alpha_adaptinC2
|
| Gene Ontology |
GO:0030119--C:AP-type membrane coat adaptor complex
GO:0030131--C:clathrin adaptor complex
GO:0030669--C:clathrin-coated endocytic vesicle membrane
GO:0030136--C:clathrin-coated vesicle
GO:0030665--C:clathrin-coated vesicle membrane
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0032588--C:trans-Golgi network membrane
GO:0030742--F:GTP-dependent protein binding
GO:0019894--F:kinesin binding
GO:0008565--F:protein transporter activity
GO:0017137--F:Rab GTPase binding
GO:0005215--F:transporter activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0035646--P:endosome to melanosome transport
GO:0090160--P:Golgi to lysosome transport
GO:0006886--P:intracellular protein transport
GO:0032438--P:melanosome organization
GO:0061024--P:membrane organization
GO:0043323--P:positive regulation of natural killer cell degranulation
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0006892--P:post-Golgi vesicle-mediated transport
GO:0050690--P:regulation of defense response to virus by virus
GO:0016032--P:viral process
|
