| Tag |
Content |
| dbPAF ID |
dbPAF-0001629 |
| Uniprot Accession |
O43745; CHP2_HUMAN; A8K2I8;
|
| Genbank Protein ID |
NP_071380.1;
|
| Genbank Nucleotide ID |
NM_022097.3;
|
| Protein Name |
Calcineurin B homologous protein 2 |
| Protein Synonyms/Alias |
Hepatocellular carcinoma-associated antigen 520; |
| Gene Name |
CHP2 |
| Gene Synonyms/Alias |
HCA520; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.Functional Description
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. |
Phosphorylation Sites
|
dbPAF PTMs: 3 |
Sequence
(Fasta) | MGSRSSHAAV IPDGDSIRRE TGFSQASLLR LHHRFRALDR NKKGYLSRMD LQQIGALAVN 60
PLGDRIIESF FPDGSQRVDF PGFVRVLAHF RPVEDEDTET QDPKKPEPLN SRRNKLHYAF 120
QLYDLDRDGK ISRHEMLQVL RLMVGVQVTE EQLENIADRT VQEADEDGDG AVSFVEFTKS 180
LEKMDVEQKM SIRILK
197Fasta Sequence
>O43745|CHP2|Homo sapiens(Human)
MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKGYLSRMDLQQIGALAVNPLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQDPKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRTVQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK
|
| Keyword |
KW-0002--3D-structure
KW-0106--Calcium
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
|
| Interpro |
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
|
| PROSITE |
PS00018--EF_HAND_1
PS50222--EF_HAND_2
|
| Pfam |
PF13499--EF-hand_7
|
| Gene Ontology |
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0071277--P:cellular response to calcium ion
GO:0070886--P:positive regulation of calcineurin-NFAT signaling cascade
GO:0008284--P:positive regulation of cell proliferation
GO:0010922--P:positive regulation of phosphatase activity
GO:0042307--P:positive regulation of protein import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0015031--P:protein transport
|
