dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001628
Uniprot Accession O43741; AAKB2_HUMAN; A8K9V5; B4DH06; Q5VXY0;
Genbank Protein ID NP_005390.1;
Genbank Nucleotide ID NM_005399.4;
Protein Name 5'-AMP-activated protein kinase subunit beta-2
Protein Synonyms/Alias
Gene Name PRKAB2
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Phosphorylation Sites
 dbPAF PTMs: 21 (View all)
PositionPeptidesSourceReferences ( PMIDs )
21HGAKAARSEGAGGHAPhosphoSitePlus;curated22135298; 22798277
39EHKIMVGSTDDPSVFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;curated18669648; 16381945; 23193290; 18691976; 19276368; 19413330;
40HKIMVGSTDDPSVFSdbPTM 3.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated20058876; 21659604; 16381945; 23193290; 19413330; 20068231;
47TDDPSVFSLPDSKLPPhosphoSitePlus22135298
61PGDKEFVSWQQDLEDPhosphoSitePlus22135298
93GGKEVFISGSFNNWSPhosphoSitePlus22135298
95KEVFISGSFNNWSTKPhosphoSitePlus;UniProt22135298; 24275569
108TKIPLIKSHNDFVAIdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18318008; 18669648; 18691976; 19369195; 19690332; 16381945;
148VVTSQLGTINNLIHVdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt20166139; 16381945; 23193290; 18988627; 22135298; 24275569
158NLIHVKKSDFEVFDAdbPTM 3.0;HPRD 9;PhosphoSitePlus;UniProt;curated20166139; 16381945; 23193290; 18988627; 22135298; 24275569;
170FDALKLDSMESSETSPhosphoSitePlus;UniProt;curated22135298; 24275569; 22798277
173LKLDSMESSETSCRDdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated20166139; 16381945; 23193290; 18988627; 22135298; 23898821;
182ETSCRDLSSSPPGPYdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 18669648; 19276368; 20068231;
183TSCRDLSSSPPGPYGdbPTM 3.0;HPRD 9;PhosphoPep 2.0;PhosphoSitePlus;curated19369195; 16381945; 23193290; 18187866; 19415658; 20815410;
184SCRDLSSSPPGPYGQdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated18669648; 18691976; 19369195; 19413330; 16381945; 23193290;
189SSSPPGPYGQEMYAFdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PhosphoSitePlus;curated18669648; 16381945; 23193290; 18988627; 22135298; 23403867;
194GPYGQEMYAFRSEERPhosphoSitePlus22135298
256SVMVLSATHRYKKKYPhosphoSitePlus22135298
263THRYKKKYVTTLLYKPhosphoSitePlus;curated22135298; 26074081
265RYKKKYVTTLLYKPIcurated26074081
Sequence
(Fasta)		MGNTTSDRVS GERHGAKAAR SEGAGGHAPG KEHKIMVGST DDPSVFSLPD SKLPGDKEFV 60
SWQQDLEDSV KPTQQARPTV IRWSEGGKEV FISGSFNNWS TKIPLIKSHN DFVAILDLPE 120
GEHQYKFFVD GQWVHDPSEP VVTSQLGTIN NLIHVKKSDF EVFDALKLDS MESSETSCRD 180
LSSSPPGPYG QEMYAFRSEE RFKSPPILPP HLLQVILNKD TNISCDPALL PEPNHVMLNH 240
LYALSIKDSV MVLSATHRYK KKYVTTLLYK PI 273
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0275--Fatty acid biosynthesis
KW-0276--Fatty acid metabolism
KW-0444--Lipid biosynthesis
KW-0443--Lipid metabolism
KW-0597--Phosphoprotein
KW-1185--Reference proteome
Interpro

IPR032640--AMPK1_CBM
IPR030081--AMPK_beta-2
IPR006828--ASC_dom
IPR014756--Ig_E-set
PROSITE
Pfam

PF16561--AMPK1_CBM
PF04739--AMPKBI
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0042802--F:identical protein binding
GO:0006853--P:carnitine shuttle
GO:0007050--P:cell cycle arrest
GO:0044255--P:cellular lipid metabolic process
GO:0006112--P:energy reserve metabolic process
GO:0006633--P:fatty acid biosynthetic process
GO:0010467--P:gene expression
GO:0008286--P:insulin receptor signaling pathway
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:0007005--P:mitochondrion organization
GO:0006996--P:organelle organization
GO:0006468--P:protein phosphorylation
GO:0042304--P:regulation of fatty acid biosynthetic process
GO:0045859--P:regulation of protein kinase activity
GO:0007165--P:signal transduction
GO:0044281--P:small molecule metabolic process
GO:0006367--P:transcription initiation from RNA polymerase II promoter