dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001624
Uniprot Accession O43731; ERD23_HUMAN; A8K7T7; B8ZZ26; O95557; Q4V750; Q4V767; Q53FP4; Q53GK1;
Genbank Protein ID NP_006846.1; NP_057839.1;
Genbank Nucleotide ID NM_006855.3; NM_016657.2;
Protein Name ER lumen protein-retaining receptor 3
Protein Synonyms/Alias KDEL endoplasmic reticulum protein retention receptor 3;KDEL receptor 3;
Gene Name KDELR3
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity).
Phosphorylation Sites
 dbPAF PTMs: 2
PositionPeptidesSourceReferences ( PMIDs )
11FRILGDLSHLLAMILPhosphoSitePlus22135298
209VLKGKKLSLPMPI--curated25850435
Sequence
(Fasta)		MNVFRILGDL SHLLAMILLL GKIWRSKCCK GISGKSQILF ALVFTTRYLD LFTNFISIYN 60
TVMKVVFLLC AYVTVYMIYG KFRKTFDSEN DTFRLEFLLV PVIGLSFLEN YSFTLLEILW 120
TFSIYLESVA ILPQLFMISK TGEAETITTH YLFFLGLYRA LYLANWIRRY QTENFYDQIA 180
VVSGVVQTIF YCDFFYLYVT KVLKGKKLSL PMPI 215
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0931--ER-Golgi transport
KW-0472--Membrane
KW-0621--Polymorphism
KW-0653--Protein transport
KW-0675--Receptor
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0813--Transport
Interpro

IPR000133--ER_ret_rcpt
PROSITE

PS00951--ER_LUMEN_RECEPTOR_1
PS00952--ER_LUMEN_RECEPTOR_2
Pfam

PF00810--ER_lumen_recept
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0046923--F:ER retention sequence binding
GO:0044267--P:cellular protein metabolic process
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0036498--P:IRE1-mediated unfolded protein response
GO:0006621--P:protein retention in ER lumen
GO:0015031--P:protein transport
GO:0016192--P:vesicle-mediated transport