dbPAF Protein Information

Tag Content
dbPAF ID dbPAF-0001623
Uniprot Accession O43719; HTSF1_HUMAN; D3DWG9; Q59G06; Q99730;
Genbank Protein ID NP_001156752.1; NP_055315.2; XP_005262461.1;
Genbank Nucleotide ID NM_001163280.1; NM_014500.4; XM_005262404.3;
Protein Name HIV Tat-specific factor 1
Protein Synonyms/Alias
Gene Name HTATSF1
Gene Synonyms/Alias
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)		 Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.
Phosphorylation Sites
 dbPAF PTMs: 66 (View all)
PositionPeptidesSourceReferences ( PMIDs )
2------MSGTNLDGNdbPTM 3.0;HPRD 9;PhosphoSitePlus;curated19664995; 16381945; 23193290; 20068231; 18988627; 22135298;
4----MSGTNLDGNDEdbPTM 3.0;HPRD 9;PhosphoSitePlus19664995; 16381945; 23193290; 18988627; 22135298
22QLRMQELYGDGKDGDPhosphoSitePlus22135298
30GDGKDGDTQTDAGGEPhosphoSitePlus;curated22135298; 25627689; 23090842
32GKDGDTQTDAGGEPDPhosphoSitePlus;curated22135298; 25627689
40DAGGEPDSLGQQPTDPhosphoSitePlus;curated22135298; 25627689
48LGQQPTDTPYEWDLDPhosphoSitePlus22135298
50QQPTDTPYEWDLDKKPhosphoSitePlus;curated22135298; 22817900
71TEDFIATYQANYGFSPhosphoSitePlus22135298
75IATYQANYGFSNDGAPhosphoSitePlus22135298
78YQANYGFSNDGASSSPhosphoSitePlus22135298
122GEKRKAESGWFHVEEPhosphoSitePlus;curated22135298; 25627689
154DEFIQLMSKFGIIMRPhosphoSitePlus22135298
224KFQLKGEYDASKKKKPhosphoSitePlus22135298
241KDYKKKLSMQQKQLDdbPTM 3.0;PhosphoSitePlus;curated22115753; 16381945; 23193290; 22135298; 26074081
327RDPEEADYCIQTLDGPhosphoSitePlus22135298
358TDYQVEETSREREERcurated23898821
385ANRGLRRSDSVSASEPhosphoSitePlus;curated22135298; 23898821; 23090842; 26074081
387RGLRRSDSVSASERAdbPTM 3.0;Phospho.ELM 9.0;HPRD 9;PHOSIDA;PhosphoPep 2.0;PhosphoSitePlus;SysPTM 2.0;UniProt;curated17081983; 16381945; 23193290; 20068231; 20164059; 21406692;
391RSDSVSASERAGPSRdbPTM 3.0;HPRD 9;PhosphoSitePlus;SysPTM 2.0;curated18212344; 16381945; 23193290; 18988627; 22135298; 19366988
Sequence
(Fasta)		MSGTNLDGND EFDEQLRMQE LYGDGKDGDT QTDAGGEPDS LGQQPTDTPY EWDLDKKAWF 60
PKITEDFIAT YQANYGFSND GASSSTANVE DVHARTAEEP PQEKAPEPTD ARKKGEKRKA 120
ESGWFHVEED RNTNVYVSGL PPDITVDEFI QLMSKFGIIM RDPQTEEFKV KLYKDNQGNL 180
KGDGLCCYLK RESVELALKL LDEDEIRGYK LHVEVAKFQL KGEYDASKKK KKCKDYKKKL 240
SMQQKQLDWR PERRAGPSRM RHERVVIIKN MFHPMDFEDD PLVLNEIRED LRVECSKFGQ 300
IRKLLLFDRH PDGVASVSFR DPEEADYCIQ TLDGRWFGGR QITAQAWDGT TDYQVEETSR 360
EREERLRGWE AFLNAPEANR GLRRSDSVSA SERAGPSRAR HFSEHPSTSK MNAQETATGM 420
AFEEPIDEKK FEKTEDGGEF EEGASENNAK ESSPEKEAEE GCPEKESEEG CPKRGFEGSC 480
SQKESEEGNP VRGSEEDSPK KESKKKTLKN DCEENGLAKE SEDDLNKESE EEVGPTKESE 540
EDDSEKESDE DCSEKQSEDG SEREFEENGL EKDLDEEGSE KELHENVLDK ELEENDSENS 600
EFEDDGSEKV LDEEGSEREF DEDSDEKEEE EDTYEKVFDD ESDEKEDEEY ADEKGLEAAD 660
KKAEEGDADE KLFEESDDKE DEDADGKEVE DADEKLFEDD DSNEKLFDEE EDSSEKLFDD 720
SDERGTLGGF GSVEEGPLST GSSFILSSDD DDDDI 756
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
PROSITE

PS50102--RRM
Pfam

PF00076--RRM_1
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005686--C:U2 snRNP
GO:0005684--C:U2-type spliceosomal complex
GO:0000166--F:nucleotide binding
GO:0044822--F:poly(A) RNA binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0032784--P:regulation of DNA-templated transcription, elongation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
GO:0019079--P:viral genome replication