| Tag |
Content |
| dbPAF ID |
dbPAF-0001622 |
| Uniprot Accession |
O43715; TRIA1_HUMAN; B2R4Z7; Q5RKS5; Q6LCA7;
|
| Genbank Protein ID |
NP_057483.1;
|
| Genbank Nucleotide ID |
NM_016399.2;
|
| Protein Name |
TP53-regulated inhibitor of apoptosis 1 |
| Protein Synonyms/Alias |
Protein 15E1.1;WF-1;p53-inducible cell-survival factor;p53CSV; |
| Gene Name |
TRIAP1 |
| Gene Synonyms/Alias |
15E1.1;HSPC132; |
| Organism |
Homo sapiens(Human) |
| NCBI Taxa ID |
9606 |
Functional Description
(View all) |
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis.Functional Description
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. |
Phosphorylation Sites
|
dbPAF PTMs: 1 | Position | Peptides | Source | References ( PMIDs ) |
|---|
| 32 | EKFLKGDSSGDPCTD | curated | 25627689 |
|
Sequence
(Fasta) | MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK AIKEKEIPIE 60
GLEFMGHGKE KPENSS
77Fasta Sequence
>O43715|TRIAP1|Homo sapiens(Human)
MNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS
|
| Keyword |
KW-0007--Acetylation
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0445--Lipid transport
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0813--Transport
|
| Interpro |
IPR007918--MDM35_apoptosis
|
| PROSITE |
|
| Pfam |
PF05254--UPF0203
|
| Gene Ontology |
GO:0005758--C:mitochondrial intermembrane space
GO:0005739--C:mitochondrion
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0002039--F:p53 binding
GO:0034644--P:cellular response to UV
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0043066--P:negative regulation of apoptotic process
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902166--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:0015914--P:phospholipid transport
GO:2001140--P:positive regulation of phospholipid transport
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0097035--P:regulation of membrane lipid distribution
|
