dbPAF Protein Information


Tag Content
dbPAF ID dbPAF-0001620
Uniprot Accession O43709; WBS22_HUMAN; A8K501; C9K060; Q96P12; Q9BQ58; Q9HBP9;
Genbank Protein ID NP_001189489.1; NP_059998.2;
Genbank Nucleotide ID NM_001202560.2; NM_017528.4;
Protein Name Probable 18S rRNA (guanine-N(7))-methyltransferase
Protein Synonyms/Alias Bud site selection protein 23 homolog;Metastasis-related methyltransferase 1;Williams-Beuren syndrome chromosomal region 22 protein;
Gene Name WBSCR22
Gene Synonyms/Alias MERM1;HUSSY-03;PP3381;
Organism Homo sapiens(Human)
NCBI Taxa ID 9606
Functional Description
(View all)
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (By similarity). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).
Phosphorylation Sites
dbPAF PTMs: 5
PositionPeptidesSourceReferences ( PMIDs )
135LCNANKKSENPAKRLcurated22817900
240ERFPLRMSRRGMVRKPhosphoSitePlus;curated22135298; 23917254; 23186163; 26074081; 24961811
248RRGMVRKSRAWVLEKPhosphoSitePlus;curated22135298; 25627689; 23898821
272EVRPDTQYTGRKRKPPhosphoSitePlus22135298
273VRPDTQYTGRKRKPRPhosphoSitePlus22135298
Sequence
(Fasta)
MASRGRRPEH GGPPELFYDE TEARKYVRNS RMIDIQTRMA GRALELLYLP ENKPCYLLDI 60
GCGTGLSGSY LSDEGHYWVG LDISPAMLDE AVDREIEGDL LLGDMGQGIP FKPGTFDGCI 120
SISAVQWLCN ANKKSENPAK RLYCFFASLF SVLVRGSRAV LQLYPENSEQ LELITTQATK 180
AGFSGGMVVD YPNSAKAKKF YLCLFSGPST FIPEGLSENQ DEVEPRESVF TNERFPLRMS 240
RRGMVRKSRA WVLEKKERHR RQGREVRPDT QYTGRKRKPR F 282
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0856--Williams-Beuren syndrome

Interpro

IPR013216--Methyltransf_11
IPR029063--SAM-dependent_MTases
IPR022238--Unchr_MeTrfase_Williams-Beuren

PROSITE
Pfam

PF08241--Methyltransf_11
PF12589--WBS_methylT

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0008168--F:methyltransferase activity
GO:0044822--F:poly(A) RNA binding
GO:0016568--P:chromatin modification
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006364--P:rRNA processing
GO:0006351--P:transcription, DNA-templated