dbPAF Protein Information
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dbPAF ID | dbPAF-0001620 | ||||||||||||||||||||||||
Uniprot Accession | O43709; WBS22_HUMAN; A8K501; C9K060; Q96P12; Q9BQ58; Q9HBP9; | ||||||||||||||||||||||||
Genbank Protein ID | NP_001189489.1; NP_059998.2; | ||||||||||||||||||||||||
Genbank Nucleotide ID | NM_001202560.2; NM_017528.4; | ||||||||||||||||||||||||
Protein Name | Probable 18S rRNA (guanine-N(7))-methyltransferase | ||||||||||||||||||||||||
Protein Synonyms/Alias | Bud site selection protein 23 homolog;Metastasis-related methyltransferase 1;Williams-Beuren syndrome chromosomal region 22 protein; | ||||||||||||||||||||||||
Gene Name | WBSCR22 | ||||||||||||||||||||||||
Gene Synonyms/Alias | MERM1;HUSSY-03;PP3381; | ||||||||||||||||||||||||
Organism | Homo sapiens(Human) | ||||||||||||||||||||||||
NCBI Taxa ID | 9606 | ||||||||||||||||||||||||
Functional Description (View all) |
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (By similarity). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492). | ||||||||||||||||||||||||
Phosphorylation Sites |
dbPAF PTMs: 5
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Sequence (Fasta) | MASRGRRPEH GGPPELFYDE TEARKYVRNS RMIDIQTRMA GRALELLYLP ENKPCYLLDI 60 GCGTGLSGSY LSDEGHYWVG LDISPAMLDE AVDREIEGDL LLGDMGQGIP FKPGTFDGCI 120 SISAVQWLCN ANKKSENPAK RLYCFFASLF SVLVRGSRAV LQLYPENSEQ LELITTQATK 180 AGFSGGMVVD YPNSAKAKKF YLCLFSGPST FIPEGLSENQ DEVEPRESVF TNERFPLRMS 240 RRGMVRKSRA WVLEKKERHR RQGREVRPDT QYTGRKRKPR F 282 |
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Keyword | KW-0025--Alternative splicing |
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Interpro | IPR013216--Methyltransf_11 |
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PROSITE | |||||||||||||||||||||||||
Pfam | |||||||||||||||||||||||||
Gene Ontology | GO:0005737--C:cytoplasm |